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Lexitral PharmaPak II

Lexitral PharmaPak II is a combination medication that contains hydrocodone and acetaminophen. It is primarily prescribed for the management of moderate to moderately severe pain. The hydrocodone component is an opioid analgesic that provides pain relief, while acetaminophen enhances the pain-relieving effects and reduces fever.



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Frequently Asked Questions

How quickly does Lexitral PharmaPak II provide pain relief?
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Patients may begin to feel relief within 30 to 60 minutes after taking the medication.

Can I take Lexitral PharmaPak II with food?
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It can be taken with or without food, but taking it with food may help reduce nausea.

What should I do if I miss a dose?
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If you miss a dose and it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while taking Lexitral PharmaPak II?
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There are no specific dietary restrictions, but avoid alcohol and consult your healthcare provider about any concerns.

Is Lexitral PharmaPak II safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using this medication.

Comprehensive Drug Guide

How Does Lexitral PharmaPak II Work?

  • Hydrocodone works by binding to opioid receptors in the brain and spinal cord, altering the perception of pain and emotional response to pain.
  • Acetaminophen acts centrally in the brain to reduce pain and fever, although its exact mechanism is not fully understood.


Common Dosages

  • Hydrocodone: 5 mg, 7.5 mg, or 10 mg
  • Acetaminophen: 325 mg or 500 mg

Typical Dosing

  • The usual dose for adults is one tablet every 4 to 6 hours as needed for pain, not exceeding the prescribed daily limit, typically no more than 4,000 mg of acetaminophen per day.


Typical Dosing

FDA Approved Indications

  • Management of Moderate to Moderately Severe Pain: to relieve pain following surgery, injury, or chronic conditions.


Who Shouldn't Take Lexitral PharmaPak II?

  • Known hypersensitivity to hydrocodone, acetaminophen, or any other components of the formulation.
  • Severe respiratory depression or acute asthma.
  • Significant liver impairment or active liver disease.


Advice From The Pharmacist

  • Take Lexitral PharmaPak II exactly as prescribed, and do not exceed the recommended dosage to avoid the risk of overdose.
  • Monitor for signs of addiction, especially if used for an extended period.
  • Avoid alcohol and other CNS depressants while taking this medication, as they can increase the risk of serious side effects.


Side Effects of Lexitral PharmaPak II

Common Side Effects

  • Drowsiness or sedation
  • Dizziness
  • Nausea or vomiting
  • Constipation


Uncommon/Severe Side Effects

  • Respiratory depression (slow or difficult breathing)
  • Signs of an allergic reaction (rash, itching, swelling)
  • Liver damage due to acetaminophen overdose.


Risks and Warnings of Lexitral PharmaPak II

  • Addiction and Abuse: There is a risk of physical dependence and addiction, particularly in individuals with a history of substance use disorders.
  • Respiratory Depression: Monitor for signs of respiratory depression, especially when starting treatment or increasing the dose.
  • Hepatotoxicity: Be cautious about the total daily dose of acetaminophen, as excessive intake can lead to severe liver damage.


Interactions with Lexitral PharmaPak II

Common Drug Interactions

  • CNS Depressants: Concomitant use with other medications that cause sedation (e.g., benzodiazepines, alcohol) may increase the risk of respiratory depression and sedation.
  • MAO Inhibitors: Avoid using within 14 days of taking MAO inhibitors due to the risk of severe reactions.


Alternatives to Lexitral PharmaPak II

  • Other Opioid Analgesics: Such as oxycodone or morphine for pain management.
  • Non-Opioid Analgesics: Such as NSAIDs (ibuprofen, naproxen) or non-opioid acetaminophen for mild to moderate pain.
  • Combination Non-Opioid Therapies: Such as tramadol or other non-opioid analgesic combinations for similar pain relief without the use of opioids.