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Ketorolac Tromethamine
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for the short-term management of moderate to severe pain, often after surgeries or medical procedures. It is effective in reducing pain and inflammation by inhibiting the production of prostaglandins.
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Frequently Asked Questions
How long does it take for ketorolac tromethamine to start working?
Ketorolac tromethamine typically begins to relieve pain within 30 minutes to 1 hour after administration.
Can I take ketorolac tromethamine with other medications?
Always consult your healthcare provider before combining ketorolac tromethamine with other medications, especially those that affect blood clotting or other NSAIDs.
What should I do if I miss a dose of ketorolac tromethamine?
If you miss a scheduled dose, contact your healthcare provider for guidance, especially for injectable forms.
Is it safe to use ketorolac tromethamine during pregnancy?
Ketorolac tromethamine should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can ketorolac tromethamine cause weight gain?
Weight gain is not a common side effect of ketorolac tromethamine. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Ketorolac Tromethamine Work?
Ketorolac tromethamine works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are involved in the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, ketorolac alleviates pain and inflammation.
Common Dosages
- Injectable solution: Common dosages include 30 mg/mL.
- Oral tablets: Common dosages include 10 mg.
Typical Dosing
- For injectable use: The usual dose is 30 mg given intramuscularly or intravenously every 6 hours as needed, with a maximum of 120 mg in 24 hours.
- For oral use: The typical starting dose is 10 mg taken every 4 to 6 hours as needed, not to exceed 40 mg per day.
Typical Dosing
FDA Approved Indications
- Short-term management of moderate to severe pain, often following surgery or other medical procedures.
Who Shouldn't Take Ketorolac Tromethamine?
- Known hypersensitivity to ketorolac or any components of the formulation
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal impairment
- History of asthma or allergic reactions to NSAIDs
Advice From The Pharmacist
- Patients should be advised to take ketorolac with food to minimize gastrointestinal irritation.
- Encourage patients to report any signs of gastrointestinal bleeding, such as black or bloody stools.
- Inform patients about the possibility of dizziness or drowsiness and advise caution when driving or operating heavy machinery.
Side Effects of Ketorolac Tromethamine
Common Side Effects
- Nausea
- Vomiting
- Dizziness
- Abdominal pain
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding
- Kidney problems
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Ketorolac Tromethamine
- Cardiovascular Risk: NSAIDs may increase the risk of cardiovascular events, such as heart attack and stroke, particularly with long-term use.
- Gastrointestinal Risk: Prolonged use may lead to serious gastrointestinal events, including bleeding and perforation.
Interactions with Ketorolac Tromethamine
Common Drug Interactions
- Other NSAIDs: Caution is advised when using ketorolac with other NSAIDs to avoid additive effects and increased risk of gastrointestinal side effects.
- Anticoagulants: Increased risk of bleeding may occur when ketorolac is used with blood thinners like warfarin.
Alternatives to Ketorolac Tromethamine
- Other NSAIDs: Such as ibuprofen or naproxen for pain relief and inflammation.
- Acetaminophen: For mild to moderate pain without the gastrointestinal risks associated with NSAIDs.
