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Ketoprofen ER
Ketoprofen ER (extended-release) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with various conditions, such as arthritis, musculoskeletal disorders, and dysmenorrhea (menstrual pain). The extended-release formulation allows for prolonged effects and convenient once-daily dosing.
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Frequently Asked Questions
How long does it take for ketoprofen ER to start working?
Ketoprofen ER typically begins to relieve pain within 1 to 2 hours, but it may take several days for optimal effects in managing inflammation.
Can I take ketoprofen ER with other medications?
Always consult your healthcare provider before combining ketoprofen ER with other medications, especially other NSAIDs or anticoagulants.
What should I do if I miss a dose of ketoprofen ER?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use ketoprofen ER during pregnancy?
Ketoprofen ER should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can ketoprofen ER cause weight gain?
Weight gain is not a common side effect of ketoprofen ER. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Ketoprofen ER Work?
Ketoprofen works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are involved in the production of prostaglandins. Prostaglandins are compounds that mediate inflammation, pain, and fever. By reducing prostaglandin synthesis, ketoprofen alleviates pain and inflammation.
Common Dosages
- Extended-release capsules or tablets: Common dosages include 100 mg and 200 mg.
Typical Dosing
- The usual starting dose for adults is 200 mg taken once daily. The dose may be adjusted based on individual response and tolerability.
Typical Dosing
FDA Approved Indications
- Relief of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
- Management of acute pain, such as that related to surgery or injury.
Who Shouldn't Take Ketoprofen ER?
- Known hypersensitivity to ketoprofen or any components of the formulation
- Active gastrointestinal bleeding or ulcers
- Severe renal impairment
- History of asthma or allergic reactions to NSAIDs
Advice From The Pharmacist
- Patients should be advised to take ketoprofen ER with food to minimize gastrointestinal irritation.
- Encourage patients to report any signs of gastrointestinal bleeding (e.g., black or bloody stools) or severe allergic reactions.
- Inform patients about potential side effects, such as dizziness or gastrointestinal upset, and advise caution when engaging in activities requiring alertness.
Side Effects of Ketoprofen ER
Common Side Effects
- Nausea
- Abdominal pain
- Diarrhea
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Gastrointestinal bleeding
- Kidney problems
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Ketoprofen ER
- Cardiovascular Risk: NSAIDs may increase the risk of cardiovascular events, such as heart attack and stroke, particularly with long-term use.
- Gastrointestinal Risk: Prolonged use may lead to serious gastrointestinal events, including bleeding and perforation.
Interactions with Ketoprofen ER
Common Drug Interactions
- Other NSAIDs: Caution is advised when using ketoprofen with other NSAIDs to avoid additive effects and increased risk of gastrointestinal side effects.
- Anticoagulants: Increased risk of bleeding may occur when ketoprofen is used with blood thinners like warfarin.
Alternatives to Ketoprofen ER
- Other NSAIDs: Such as ibuprofen or naproxen for pain relief and inflammation.
- Acetaminophen: For mild to moderate pain without the gastrointestinal risks associated with NSAIDs.
