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Irbesartan-hydroCHLOROthiazide
Irbesartan-Hydrochlorothiazide is a combination medication that includes irbesartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic. This combination is used to treat hypertension (high blood pressure) and helps to reduce the risk of cardiovascular events. Irbesartan works by relaxing blood vessels, while hydrochlorothiazide helps reduce fluid retention, leading to lower blood pressure.
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Frequently Asked Questions
How long does it take for Irbesartan-Hydrochlorothiazide to start working?
Patients may begin to see a reduction in blood pressure within 1 to 2 weeks, but optimal control may take longer.
Can I take Irbesartan-Hydrochlorothiazide with other medications?
Always consult your healthcare provider before combining Irbesartan-Hydrochlorothiazide with other medications, especially other antihypertensives, diuretics, or medications that affect renal function.
What should I do if I miss a dose of Irbesartan-Hydrochlorothiazide?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Irbesartan-Hydrochlorothiazide during pregnancy?
Irbesartan-Hydrochlorothiazide should not be used during pregnancy due to the potential risk to the fetus. Patients should inform their healthcare provider if they become pregnant.
Can Irbesartan-Hydrochlorothiazide cause weight gain?
Weight gain is not a common side effect of Irbesartan-Hydrochlorothiazide. However, any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Irbesartan-hydroCHLOROthiazide Work?
- Irbesartan blocks the action of angiotensin II, a hormone that causes blood vessels to constrict. By preventing this action, it helps to relax and widen blood vessels, lowering blood pressure.
- Hydrochlorothiazide promotes the excretion of sodium and water by the kidneys, which helps reduce blood volume and further lowers blood pressure.
Common Dosages
- Tablets: Common dosages include 150 mg/12.5 mg, 300 mg/12.5 mg, and 300 mg/25 mg (irbesartan/hydrochlorothiazide).
Typical Dosing
- The typical starting dose for hypertension is 150 mg/12.5 mg taken once daily, which may be adjusted based on blood pressure response.
- The maximum recommended dose is 300 mg/25 mg once daily.
Typical Dosing
FDA Approved Indications
- Management of hypertension
Who Shouldn't Take Irbesartan-hydroCHLOROthiazide?
- Known hypersensitivity to irbesartan, hydrochlorothiazide, or any components of the formulation
- Severe renal impairment or anuria (inability to produce urine)
Advice From The Pharmacist
- Irbesartan-Hydrochlorothiazide should be taken at the same time each day, with or without food.
- Patients should be advised to monitor their blood pressure regularly to ensure the medication is effective.
- Advise patients to maintain adequate hydration and be aware of signs of electrolyte imbalances, such as muscle cramps or weakness.
Side Effects of Irbesartan-hydroCHLOROthiazide
Common Side Effects
- Dizziness
- Fatigue
- Headache
- Increased urination
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Low blood pressure (hypotension)
- Electrolyte imbalances (such as low potassium levels)
Risks and Warnings of Irbesartan-hydroCHLOROthiazide
- Renal Impairment: Use with caution in patients with renal impairment, as it may worsen kidney function.
- Pregnancy: Irbesartan-Hydrochlorothiazide should be discontinued as soon as pregnancy is detected due to potential harm to the fetus.
- Electrolyte Imbalances: Monitor potassium levels, as thiazide diuretics can lead to low potassium (hypokalemia).
Interactions with Irbesartan-hydroCHLOROthiazide
Common Drug Interactions
- Other Antihypertensives: Caution should be exercised when using with other blood pressure medications, as this can lead to additive hypotensive effects.
- Lithium: Co-administration with lithium may increase lithium levels and the risk of toxicity.
- NSAIDs: Nonsteroidal anti-inflammatory drugs may reduce the antihypertensive effect of Irbesartan-Hydrochlorothiazide and increase the risk of renal impairment.
Alternatives to Irbesartan-hydroCHLOROthiazide
- Irbesartan alone: For patients who may not need a diuretic.
- Other ARBs: Such as valsartan or candesartan.
- ACE Inhibitors: Such as lisinopril, which have a similar mechanism of action for blood pressure control.
