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Irbesartan
Irbesartan is an angiotensin II receptor blocker (ARB) used primarily to treat hypertension (high blood pressure) and to protect the kidneys in patients with type 2 diabetes. By blocking the effects of angiotensin II, a substance that constricts blood vessels, irbesartan helps relax blood vessels, leading to decreased blood pressure and improved blood flow.
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Frequently Asked Questions
How long does it take for irbesartan to start working?
Patients may begin to see a reduction in blood pressure within 1 to 2 weeks, but it may take several weeks for full therapeutic effects.
How long does it take for irbesartan to start working?
Patients may begin to see a reduction in blood pressure within 1 to 2 weeks, but it may take several weeks for full therapeutic effects.
Can I take irbesartan with other medications?
Always consult your healthcare provider before combining irbesartan with other medications, especially other antihypertensive agents or diuretics.
What should I do if I miss a dose of irbesartan?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use irbesartan during pregnancy?
Irbesartan should not be used during pregnancy due to potential risks to the fetus. Patients should inform their healthcare provider if they become pregnant.
Can irbesartan cause weight gain?
Weight gain is not a common side effect of irbesartan. However, any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Irbesartan Work?
Irbesartan works by selectively blocking the binding of angiotensin II to the AT1 receptor. This action prevents vasoconstriction and promotes vasodilation, leading to reduced blood pressure. It also decreases aldosterone secretion, which helps reduce fluid retention.
What is Irbesartan Used For?
Common Dosages
- Tablets: Common dosages include 75 mg, 150 mg, and 300 mg.
Typical Dosing
- The typical starting dose for hypertension is 150 mg once daily, which may be adjusted based on blood pressure response, with a maximum dose of 300 mg per day.
- For renal protection in diabetic patients, the initial dose is often 150 mg once daily.
Typical Dosing
FDA Approved Indications
- Management of hypertension
- Renal protection in patients with type 2 diabetes and hypertension
Off-Label Uses
Who Shouldn't Take Irbesartan?
- Known hypersensitivity to irbesartan or any components of the formulation
- Pregnancy, particularly in the second and third trimesters
- Severe renal impairment
Advice From The Pharmacist
- Patients should be advised to take irbesartan at the same time each day to maintain consistent blood levels.
- Regular monitoring of blood pressure and renal function is important, especially during the initiation of therapy.
- Patients should be informed about the possibility of dizziness, especially when first starting the medication or increasing the dose.
Side Effects of Irbesartan
Common Side Effects
- Dizziness or lightheadedness
- Fatigue
- Nausea
- Hypotension (low blood pressure)
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Kidney problems, including acute kidney injury
- Hyperkalemia (high potassium levels)
Risks and Warnings of Irbesartan
- Renal Function: Monitor renal function periodically, especially in patients with pre-existing kidney issues or those taking other medications that affect the kidneys.
- Pregnancy: Irbesartan is contraindicated in pregnancy due to potential harm to the fetus.
- Electrolyte Imbalances: Monitor potassium levels, as ARBs can lead to hyperkalemia.
Interactions with Irbesartan
Common Drug Interactions
- Other Antihypertensives: Caution is advised when using irbesartan with other blood pressure medications, as this can lead to additive hypotensive effects.
- NSAIDs: Nonsteroidal anti-inflammatory drugs may reduce the antihypertensive effect of irbesartan and increase the risk of renal impairment.
Common Food Interactions
Alternatives to Irbesartan
- Other Antihypertensives: Caution is advised when using irbesartan with other blood pressure medications, as this can lead to additive hypotensive effects.
- NSAIDs: Nonsteroidal anti-inflammatory drugs may reduce the antihypertensive effect of irbesartan and increase the risk of renal impairment.
