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Intuniv
Intuniv is the brand name for guanfacine extended-release, a medication primarily used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children and adolescents aged 6 to 17 years. It is also prescribed for managing symptoms associated with oppositional defiant disorder (ODD). Intuniv works by affecting certain receptors in the brain, which helps to improve attention, focus, and impulse control.
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Frequently Asked Questions
How quickly does Intuniv work?
Patients may start to notice improvements in ADHD symptoms within a few weeks of starting treatment, but it may take longer to achieve full benefits.
Can I take Intuniv with other ADHD medications?
Discuss with your healthcare provider, as Intuniv can be used alone or in combination with other ADHD medications, depending on individual needs.
What should I do if I miss a dose of Intuniv?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Intuniv safe during pregnancy?
The safety of Intuniv during pregnancy has not been established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
Can I stop taking Intuniv suddenly?
It is important not to stop taking Intuniv abruptly, as this may cause increased blood pressure and other withdrawal symptoms. Consult your healthcare provider for guidance on how to safely taper the medication if needed.
Comprehensive Drug Guide
How Does Intuniv Work?
Guanfacine works by selectively stimulating alpha-2 adrenergic receptors in the prefrontal cortex of the brain. This stimulation results in increased attention and improved regulation of behavior by enhancing prefrontal cortical function, which is involved in executive functions such as attention and impulse control. By modulating norepinephrine release, guanfacine helps reduce hyperactivity and improve focus.
Common Dosages
- Starting dose: 1 mg once daily.
- Titration: The dosage may be increased in increments of 0.5 mg to 1 mg per week, up to a maximum of 4 mg per day, based on clinical response and tolerability.
Typical Dosing
- For ADHD: Begin with 1 mg once daily. Depending on the response, the dosage may be adjusted in weekly increments, not exceeding 4 mg daily.
Typical Dosing
FDA Approved Indications
- Treatment of ADHD in children and adolescents aged 6 to 17 years.
- Treatment of oppositional defiant disorder (ODD) in the same age group.
Who Shouldn't Take Intuniv?
- Known hypersensitivity to guanfacine or any components of the formulation.
- Severe cardiovascular disease, including significant bradycardia, hypotension, or heart block.
Advice From The Pharmacist
- Take Intuniv as prescribed: Follow your healthcare provider's instructions regarding dosing and timing. It is typically taken once daily and should not be crushed or chewed.
- Monitor for side effects: Common side effects may include drowsiness, fatigue, dry mouth, and constipation. Report any severe or concerning symptoms to your healthcare provider.
- Avoid abrupt discontinuation: Stopping Intuniv suddenly may lead to increased blood pressure. Consult your healthcare provider for a tapering schedule if discontinuation is necessary.
- Store Intuniv at room temperature, away from moisture and heat, and keep it out of reach of children.
Side Effects of Intuniv
Common Side Effects
- Drowsiness or sedation
- Fatigue
- Dry mouth
- Constipation
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing)
- Bradycardia: Low heart rate, particularly in individuals with preexisting cardiovascular conditions.
Risks and Warnings of Intuniv
- Sedation: Intuniv can cause significant drowsiness, particularly when starting the medication or increasing the dose. Caution is advised when driving or operating machinery.
- Cardiovascular Effects: Monitor heart rate and blood pressure, as Intuniv can cause bradycardia and hypotension, especially in patients with a history of cardiovascular disease.
- Mental Health Monitoring: Regular assessment of mood and behavior is essential, particularly in pediatric patients, to monitor for any signs of depression or worsening of symptoms.
Interactions with Intuniv
Common Drug Interactions
- CNS depressants: Concurrent use may increase sedative effects, necessitating caution.
- Other antihypertensive medications: Can lead to increased risk of hypotension.
Alternatives to Intuniv
- Other ADHD medications: Such as methylphenidate (Ritalin) or amphetamines (Adderall), which are stimulant medications commonly used to treat ADHD.
- Non-stimulant medications: Such as atomoxetine (Strattera) or other alpha-2 adrenergic agonists like clonidine.
