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Guanfacine HCl

Guanfacine HCl is an alpha-2 adrenergic agonist used for the treatment of attention deficit hyperactivity disorder (ADHD) and for managing hypertension. It helps improve attention and impulse control in patients with ADHD and lowers blood pressure by decreasing sympathetic nervous system output.



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Frequently Asked Questions

How long does it take for Guanfacine HCl to work for ADHD?
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Some patients may notice improvement within a week, but full effects may take several weeks to establish.

Can I take Guanfacine HCl while pregnant?
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Consult your healthcare provider for guidance, as the benefits must be weighed against potential risks during pregnancy.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.

Are there any specific storage instructions for Guanfacine HCl?
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Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.

Is Guanfacine HCl safe for long-term use?
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Guanfacine HCl can be used long-term, but regular monitoring for side effects and overall effectiveness is important.

Comprehensive Drug Guide

How Does Guanfacine HCl Work?

Guanfacine HCl works by stimulating alpha-2 adrenergic receptors in the brain, which leads to a reduction in sympathetic outflow. This action helps decrease blood pressure and enhances focus and impulse control by modulating neurotransmitter release.



What is Guanfacine HCl Used For?


Common Dosages

Guanfacine HCl is available in the following forms:

  • Immediate-release tablets: Common strengths include 1 mg and 2 mg.
  • Extended-release tablets: Common strengths include 1 mg, 2 mg, and 3 mg.

Typical Dosing

The typical dosing for Guanfacine HCl is:

  • For ADHD: The starting dose for the immediate-release form is typically 1 mg once daily, which may be adjusted based on clinical response.
  • For Hypertension: The initial dose may be 1 mg to 2 mg taken once daily, adjusted as needed.

Typical Dosing

FDA Approved Indications

  • Treatment of ADHD as part of a comprehensive treatment program.
  • Management of hypertension, typically in combination with other antihypertensive agents.

Off-Label Uses

It can be used for Filles de la Tourette’s syndrome, opioid withdrawal, and renovascular hypertension

Pediatric Dosing

  • Dosage for children depends on the condition being treated and the child's age and weight. Instructions from the doctor should be strictly followed.
  • For ADHD, the dose is usually based on weight and age. The starting dose can be 1mg daily and gradually increased if necessary.
  • Parents should watch out for noteworthy changes in behavior, sleep patterns, or unusual tiredness.
  • The medicine should not be discontinued abruptly, doctors usually recommend a gradual dose reduction.

Who Shouldn't Take Guanfacine HCl?

  • Hypersensitivity: Known hypersensitivity to guanfacine or any components of the formulation.
  • Severe Coronary Artery Disease: Use with caution in patients with severe coronary artery disease.

Advice From The Pharmacist

  • How to Take: Take Guanfacine HCl exactly as prescribed. It can be taken with or without food.
  • Avoid Abrupt Discontinuation: Gradual dose tapering is recommended to prevent rebound hypertension.
  • Monitor Symptoms: Regular follow-up is essential to assess the effectiveness and any side effects.

Side Effects of Guanfacine HCl

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Fatigue
  • Constipation

Uncommon/Severe Side Effects

  • Bradycardia: Slow heart rate.
  • Hypotension: Low blood pressure, particularly with rapid dose adjustments.

Risks and Warnings of Guanfacine HCl

  • Sedation Risk: Patients should be cautioned about activities requiring alertness until they know how the medication affects them.
  • Monitoring Required: Regular follow-up appointments are necessary to monitor blood pressure and overall response to treatment.

Interactions with Guanfacine HCl

Common Drug Interactions

  • Drug Interactions: Guanfacine HCl may interact with other medications that lower blood pressure or CNS depressants. Always inform your healthcare provider about all medications you are taking.
  • Food Interactions: No significant food interactions are noted.

Alternatives to Guanfacine HCl

  • Other Stimulants: Such as methylphenidate or amphetamine-based medications.
  • Non-stimulant Options: Such as atomoxetine for ADHD.