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Indomethacin ER
Indomethacin ER (extended-release) is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, swelling, and inflammation associated with various conditions such as arthritis, tendinitis, and bursitis. It works by inhibiting the production of certain chemicals in the body that cause inflammation and pain, providing relief for individuals suffering from these conditions.
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Frequently Asked Questions
How long does it take for Indomethacin ER to start working?
Patients may begin to feel relief within a few hours, but it may take several days for the full benefits to be realized.
Can I take Indomethacin ER with other medications?
Always consult your healthcare provider before combining Indomethacin ER with other medications, especially other NSAIDs, blood thinners, or medications that affect kidney function.
What should I do if I miss a dose of Indomethacin ER?
If you miss a dose, take it as soon as you remember. If it's close to the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Is it safe to use Indomethacin ER during pregnancy?
Indomethacin ER should be used during pregnancy only if clearly needed and prescribed by a healthcare provider, particularly in the third trimester due to potential risks.
Can Indomethacin ER cause weight gain?
Weight gain can occur as a side effect due to fluid retention, so patients should monitor their weight and discuss any concerns with their healthcare provider.
Comprehensive Drug Guide
How Does Indomethacin ER Work?
Indomethacin ER works by inhibiting the activity of cyclooxygenase enzymes (COX-1 and COX-2), which play a key role in the synthesis of prostaglandins—chemicals in the body that mediate inflammation and pain. By blocking these enzymes, indomethacin reduces the levels of prostaglandins, leading to decreased inflammation, pain relief, and lower fever.
Common Dosages
- Extended-release capsules: Typically 75 mg and 100 mg.
Typical Dosing
- The usual starting dose for adults is 150 mg per day, which may be adjusted based on the condition being treated and the patient's response. The maximum daily dose should not exceed 200 mg.
- The capsules should be taken with food to minimize gastrointestinal side effects.
Typical Dosing
FDA Approved Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Acute gouty arthritis
- Pain and inflammation associated with other musculoskeletal disorders
Who Shouldn't Take Indomethacin ER?
- Known hypersensitivity to indomethacin or any components of the formulation
- Active gastrointestinal bleeding or ulceration
- Severe renal impairment
- History of asthma or allergic reactions to NSAIDs
Advice From The Pharmacist
- Indomethacin ER should be taken consistently at the same time each day to maintain steady levels of the medication in the body.
- Always take with food or milk to help reduce gastrointestinal irritation.
- Monitor for signs of gastrointestinal bleeding (such as black stools or abdominal pain) and report any such symptoms to a healthcare provider immediately.
- Patients should be informed about the potential risk of cardiovascular events associated with long-term use of NSAIDs.
Side Effects of Indomethacin ER
Common Side Effects
- Gastrointestinal upset (nausea, vomiting, diarrhea)
- Headache
- Dizziness
- Stomach pain
Uncommon/Severe Side Effects
- Gastrointestinal bleeding or ulceration
- Increased blood pressure
- Kidney problems
Risks and Warnings of Indomethacin ER
- Gastrointestinal Risks: NSAIDs can cause serious gastrointestinal issues, including bleeding, ulceration, and perforation.
- Cardiovascular Risks: Long-term use may increase the risk of heart attack or stroke, particularly in individuals with existing heart disease.
- Renal Effects: Monitor kidney function in patients taking Indomethacin ER, especially those with pre-existing kidney issues.
Interactions with Indomethacin ER
Common Drug Interactions
- Anticoagulants: Indomethacin may increase the risk of bleeding when taken with blood thinners like warfarin.
- Other NSAIDs: Using multiple NSAIDs concurrently can increase the risk of gastrointestinal side effects.
- Diuretics and ACE Inhibitors: Indomethacin may reduce the effectiveness of these medications.
Alternatives to Indomethacin ER
- Naproxen: Another NSAID commonly used for pain and inflammation.
- Ibuprofen: A widely used NSAID for various inflammatory conditions.
- Celecoxib (Celebrex): A COX-2 selective inhibitor that may have a lower risk of gastrointestinal side effects.
