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Ilumya
Ilumya is the brand name for tildrakizumab-asmn, a humanized monoclonal antibody used in the treatment of plaque psoriasis in adults. It is an interleukin-23 (IL-23) inhibitor that targets the p19 subunit of IL-23, a cytokine involved in inflammatory processes. By inhibiting IL-23, Ilumya helps reduce inflammation and the overproduction of skin cells associated with psoriasis, leading to clearer skin and improved symptoms.
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Frequently Asked Questions
How quickly does Ilumya work?
Many patients may start to see improvements in their psoriasis symptoms within 12 weeks of starting treatment, although some may see results sooner.
Can I use Ilumya with other psoriasis treatments?
Discuss with your healthcare provider, as Ilumya can be used alone or in combination with other treatments, but some combinations may not be recommended.
What should I do if I miss a dose of Ilumya?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Ilumya safe during pregnancy?
The safety of Ilumya during pregnancy has not been fully established. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
Can I stop using Ilumya if my symptoms improve?
It's important to continue using Ilumya as prescribed, even if your symptoms improve. Consult your healthcare provider before making any changes to your treatment plan to ensure continued effectiveness and safety.
Comprehensive Drug Guide
How Does Ilumya Work?
Tildrakizumab-asmn works by selectively binding to the p19 subunit of interleukin-23, blocking its interaction with the IL-23 receptor. This action inhibits the signaling pathway that leads to the activation of inflammatory responses and the proliferation of skin cells. By targeting IL-23, Ilumya reduces the activity of inflammatory cells and helps restore normal skin cell function, resulting in a reduction of psoriatic plaques.
Common Dosages
- Initial dose: 100 mg administered subcutaneously at week 0 and week 4.
- Maintenance dose: After the initial dosing period, the maintenance dose is 100 mg every 12 weeks.
Typical Dosing
- For plaque psoriasis: Administer 100 mg subcutaneously at week 0, followed by another 100 mg at week 4. Continue with 100 mg every 12 weeks thereafter.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Who Shouldn't Take Ilumya?
- Known hypersensitivity to tildrakizumab or any components of the formulation.
- Active infections, including tuberculosis or other opportunistic infections.
Advice From The Pharmacist
- Use as prescribed: Follow your healthcare provider's instructions regarding dosing and administration. Do not miss scheduled doses for optimal results.
- Monitor for side effects: Common side effects may include injection site reactions, headache, and increased risk of infections. Report any severe or unusual symptoms to your healthcare provider.
- Screen for infections: Before starting treatment, ensure you are screened for tuberculosis and other infections, as Ilumya can increase the risk of serious infections.
- Store Ilumya in the refrigerator, and allow it to reach room temperature before administration. Keep it out of reach of children.
Side Effects of Ilumya
Common Side Effects
- Injection site reactions (redness, itching, swelling)
- Headache
- Fatigue
- Nausea
Uncommon/Severe Side Effects
- Serious infections: Such as tuberculosis or other opportunistic infections.
- Allergic reactions (e.g., rash, itching, swelling, difficulty breathing).
Risks and Warnings of Ilumya
- Infection Risk: Patients should be monitored for signs of infection, as IL-23 inhibitors can increase the risk of serious infections.
- Immunizations: Live vaccines should be avoided during treatment with Ilumya. Ensure all vaccinations are up to date before starting therapy.
- Liver function monitoring: Monitor liver enzymes as IL-23 inhibitors may affect liver function in some patients.
Interactions with Ilumya
Common Drug Interactions
- Ilumya has minimal known interactions, but patients should inform their healthcare provider about all medications they are taking, including over-the-counter drugs and supplements, to prevent potential interactions.
Alternatives to Ilumya
- Other biologics: Such as ustekinumab (Stelara) or secukinumab (Cosentyx), which also target different pathways in the treatment of psoriasis.
- Traditional systemic therapies: Such as methotrexate or cyclosporine for moderate to severe plaque psoriasis.
