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HumaLOG Mix 75/25
HumaLOG Mix 75/25 is a premixed insulin formulation that combines 75% insulin lispro protamine (an intermediate-acting insulin) and 25% insulin lispro (a rapid-acting insulin). This combination is designed to provide both immediate and extended blood sugar control for individuals with diabetes, particularly those needing flexible dosing for meal coverage.
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Frequently Asked Questions
How quickly does HumaLOG Mix 75/25 work?
The rapid-acting component begins to work within 15 minutes, while the intermediate-acting component provides longer-lasting control.
Can I take HumaLOG Mix 75/25 while pregnant?
Consult your healthcare provider for guidance, as insulin needs may change during pregnancy.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. Do not double up on doses.
Are there any specific storage instructions for HumaLOG Mix 75/25?
Store unopened vials or pens in the refrigerator. After opening, they can be stored at room temperature for up to 28 days.
Is HumaLOG Mix 75/25 safe for long-term use?
Long-term use should be monitored by a healthcare provider to manage efficacy and any potential side effects.
Comprehensive Drug Guide
How Does HumaLOG Mix 75/25 Work?
Insulin lispro works by facilitating the uptake of glucose into muscle and fat tissues and inhibiting glucose production in the liver. The rapid-acting component provides quick glucose control after meals, while the intermediate-acting component helps maintain blood sugar levels throughout the day.
Common Dosages
- Injectable solution: Available in vials and pre-filled pens, usually in concentrations of 100 units/mL.
Typical Dosing
The typical dosing for HumaLOG Mix 75/25 is:
- For Diabetes Management: The dosage is individualized based on blood glucose levels, carbohydrate intake, and overall diabetes management plans. It is generally administered subcutaneously twice daily before meals.
Typical Dosing
FDA Approved Indications
- Management of diabetes mellitus in adults and pediatric patients.
Who Shouldn't Take HumaLOG Mix 75/25?
- Hypersensitivity: Known hypersensitivity to insulin lispro or any components of the formulation.
- Severe Hypoglycemia: Should not be used in patients with low blood sugar levels.
Advice From The Pharmacist
- How to Use: Administer HumaLOG Mix 75/25 subcutaneously in the thigh, abdomen, or upper arm. Rotate injection sites to prevent lipodystrophy.
- Monitor Blood Glucose: Regularly check blood glucose levels to adjust insulin doses as needed.
- Storage: Store unopened vials or pens in the refrigerator; once in use, they can be kept at room temperature for up to 28 days.
Side Effects of HumaLOG Mix 75/25
Common Side Effects
- Hypoglycemia: Symptoms may include sweating, shaking, and confusion.
- Injection site reactions: Such as redness, swelling, or pain at the injection site.
- Weight gain: Associated with insulin therapy.
Uncommon/Severe Side Effects
- Severe allergic reactions: Such as rash, itching, or difficulty breathing.
Risks and Warnings of HumaLOG Mix 75/25
- Caution in Patients with Renal or Hepatic Impairment: Use with caution in patients with kidney or liver issues, as insulin clearance may be affected.
- Adjust Doses with Changes in Activity or Diet: Patients should be aware that changes in physical activity or dietary intake may necessitate dose adjustments.
Interactions with HumaLOG Mix 75/25
Common Drug Interactions
- Drug Interactions: HumaLOG Mix 75/25 may interact with other medications that affect blood glucose levels, including certain oral hypoglycemics and corticosteroids. Always inform your healthcare provider about all medications you are taking.
Alternatives to HumaLOG Mix 75/25
- Other Insulin Preparations: Such as HumaLOG (rapid-acting) or NPH insulin for varying management needs.
- Oral Antidiabetic Agents: Such as metformin for type 2 diabetes management.
