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Heplisav-B

Heplisav-B is a recombinant hepatitis B vaccine used for the prevention of hepatitis B virus infection in adults aged 18 years and older. It is designed to provide immunity against hepatitis B through the stimulation of the immune system, resulting in the production of antibodies to the virus.



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Frequently Asked Questions

How quickly does Heplisav-B provide protection against hepatitis B?
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Protection typically develops within 4 to 6 weeks after completing the two-dose series, but individual responses may vary.

Can I receive Heplisav-B if I am pregnant?
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Consult your healthcare provider for guidance, as vaccination during pregnancy should be evaluated based on potential risks and benefits.

What should I do if I miss a dose of Heplisav-B?
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If you miss the second dose, contact your healthcare provider for guidance on rescheduling your vaccination.

Are there any specific storage instructions for Heplisav-B?
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Store the vaccine in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Keep out of reach of children.

Is Heplisav-B safe for long-term use?
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Heplisav-B is a vaccination and is not used on a long-term basis. Follow-up vaccinations may be recommended based on risk factors and healthcare provider advice.

Comprehensive Drug Guide

How Does Heplisav-B Work?

Heplisav-B works by introducing a small amount of hepatitis B surface antigen (HBsAg) into the body. This antigen stimulates the immune system to produce antibodies against the hepatitis B virus without causing the disease, providing protection against future infections.



Common Dosages

  • Injectable solution: Administered in a 1 mL dose.

Typical Dosing

The typical dosing for Heplisav-B is:

  • For Hepatitis B Vaccination: The recommended regimen is two doses, with the second dose given at least 30 days after the first dose.


Typical Dosing

FDA Approved Indications

  • Prevention of hepatitis B virus infection in adults aged 18 years and older.


Who Shouldn't Take Heplisav-B?

  • Hypersensitivity: Known hypersensitivity to any component of the vaccine, including yeast proteins.
  • Severe Allergic Reactions: History of severe allergic reactions to a previous dose of any hepatitis B vaccine.


Advice From The Pharmacist

  • How to Use: Heplisav-B should be administered by a healthcare provider as an intramuscular injection, typically in the deltoid muscle.
  • Monitor for Side Effects: Patients should be monitored for any immediate allergic reactions following vaccination.
  • Inform Healthcare Provider: Patients should inform their healthcare provider of any history of allergies or previous vaccine reactions.


Side Effects of Heplisav-B

Common Side Effects

  • Injection site reactions: Such as pain, redness, or swelling.
  • Fatigue
  • Headache
  • Muscle pain


Uncommon/Severe Side Effects

  • Severe allergic reactions: Such as rash, itching, swelling, or difficulty breathing.


Risks and Warnings of Heplisav-B

  • Caution in Immunocompromised Patients: Use with caution in patients with weakened immune systems, as the vaccine may not be as effective.
  • Post-Vaccination Monitoring: Observe patients for at least 15 minutes after vaccination for signs of an allergic reaction.


Interactions with Heplisav-B

Common Drug Interactions

  • Drug Interactions: Heplisav-B may be administered concurrently with other vaccines, but consult with a healthcare provider regarding specific timing and administration.


Alternatives to Heplisav-B

  • Other Hepatitis B Vaccines: Such as Engerix-B or Recombivax HB, which may follow different dosing schedules.