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Engerix-B
Engerix-B is a hepatitis B vaccine used to prevent infection caused by the hepatitis B virus (HBV). Hepatitis B is a serious liver infection that can lead to liver cirrhosis, liver failure, and liver cancer. Engerix-B contains purified inactivated hepatitis B surface antigen, which helps the immune system develop antibodies to protect against the hepatitis B virus. It is used in both adults and children as part of a routine vaccination schedule and for people at higher risk of HBV infection.
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Frequently Asked Questions
How long does protection from Engerix-B last?
After completing the full vaccination schedule, protection from hepatitis B can last for at least 20 years and often for life. A booster dose may be recommended for certain high-risk individuals, but routine boosters are not typically necessary.
Can Engerix-B be given during pregnancy?
Yes, Engerix-B is considered safe for use during pregnancy, particularly for women at high risk of hepatitis B infection. It is important to discuss the benefits and risks with your healthcare provider.
What should I do if I miss a dose of Engerix-B?
If you miss a dose, contact your healthcare provider to reschedule it. It’s important to complete the full vaccine series, but you do not need to restart the series if a dose is missed. Simply continue from where you left off.
Is Engerix-B safe for children?
Yes, Engerix-B is approved for use in infants, children, and adolescents to protect against hepatitis B. It is part of the routine childhood vaccination schedule.
Can Engerix-B prevent hepatitis B if I’m already infected?
No, Engerix-B is used for prevention and is not effective in treating individuals already infected with hepatitis B. It is crucial to get vaccinated before exposure to the virus.
Comprehensive Drug Guide
How Does Engerix-B Work?
Engerix-B contains a non-infectious form of the hepatitis B surface antigen (HBsAg), which stimulates the immune system to produce antibodies against hepatitis B without causing infection. These antibodies protect the individual from future hepatitis B infection by preventing the virus from entering liver cells and replicating.
Common Dosages
The dosing schedule of Engerix-B depends on the individual’s age and risk factors:
- Pediatric dose (10 mcg/0.5 mL): Administered to infants and children under 20 years of age.
- Adult dose (20 mcg/1 mL): Administered to adults aged 20 years and older.
Typical Dosing
- Infants and Children: The typical dosing schedule is three doses at 0, 1, and 6 months of age.
- Adults: A standard dosing schedule involves three doses at 0, 1, and 6 months.
- Accelerated dosing schedule: For certain high-risk groups, an accelerated schedule of four doses at 0, 1, 2, and 12 months can be used.
Typical Dosing
FDA Approved Indications
Prevention of hepatitis B virus infection in infants, children, adolescents, and adults, including those at high risk of infection.
Who Shouldn't Take Engerix-B?
- Known hypersensitivity to yeast or any other components of the vaccine
- Severe allergic reactions (anaphylaxis) after a previous dose of hepatitis B vaccine or any vaccine component
Advice From The Pharmacist
- Engerix-B is given as an injection into the muscle (usually the deltoid muscle of the arm for adults and the thigh for infants).
- Complete the full vaccination schedule as recommended by your healthcare provider for optimal protection.
- Mild side effects such as redness or soreness at the injection site, fatigue, or mild fever are common after receiving the vaccine.
- If you are traveling to an area with a high prevalence of hepatitis B, make sure to get vaccinated well in advance.
Side Effects of Engerix-B
Common Side Effects
- Pain, redness, or swelling at the injection site
- Fatigue
- Fever
- Headache
- Irritability (in children)
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., anaphylaxis)
- Guillain-Barré syndrome (a rare neurological disorder)
- Joint pain or muscle pain
Risks and Warnings of Engerix-B
- Allergic Reactions: Severe allergic reactions (anaphylaxis) to previous doses of the vaccine or its components are contraindications. Any signs of an allergic reaction such as difficulty breathing, swelling, or rash should be reported immediately.
- Fever: Some patients may experience mild fever after receiving Engerix-B, which usually resolves within a few days.
- Immune System Concerns: Patients with weakened immune systems may not have as strong a response to the vaccine and may require additional doses or monitoring to ensure protection.
Interactions with Engerix-B
Common Drug Interactions
Immunosuppressive Drugs: Medications that suppress the immune system (such as corticosteroids, chemotherapy, or immunosuppressants) may reduce the effectiveness of the vaccine. Discuss with your healthcare provider if you are taking immunosuppressive medications.
Common Food Interactions
Alternatives to Engerix-B
- Heplisav-B: Another hepatitis B vaccine that requires only two doses administered one month apart for adults.
- Recombivax HB: A similar hepatitis B vaccine that is also used to prevent hepatitis B infection.
- Twinrix: A combination vaccine that protects against both hepatitis A and hepatitis B and is administered in a three-dose schedule.
