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Gimoti
Gimoti (metoclopramide) is a prescription medication used primarily for the treatment of gastroparesis (delayed gastric emptying) in patients with diabetes, as well as for the short-term treatment of nausea and vomiting associated with chemotherapy or surgery. It acts as a prokinetic agent, enhancing the motility of the upper gastrointestinal tract.
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Frequently Asked Questions
How quickly does Gimoti work?
Patients may start to notice improvement in symptoms within 30 minutes to 1 hour after administration.
Can I use Gimoti if I am pregnant?
Consult your healthcare provider for guidance if you are pregnant or planning to become pregnant, as the benefits must be weighed against potential risks.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the next scheduled dose, skip the missed dose and continue with your regular schedule.
Are there any specific storage instructions for Gimoti?
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Is Gimoti safe for long-term use?
Gimoti is not recommended for long-term use due to the risk of tardive dyskinesia and other side effects; regular follow-ups are essential.
Comprehensive Drug Guide
How Does Gimoti Work?
Gimoti works by blocking dopamine receptors in the gastrointestinal tract and central nervous system. This action enhances gastric motility and accelerates gastric emptying. Additionally, it increases the tone of the lower esophageal sphincter, reducing the risk of gastroesophageal reflux.
Common Dosages
Gimoti is available in the following form:
- Nasal spray: Typically available in a strength of 100 mg per spray.
Typical Dosing
The typical dosing for Gimoti is:
- For Gastroparesis: Administer 1 spray (100 mg) in one nostril 3 times daily, 30 minutes before meals and at bedtime, as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Treatment of diabetic gastroparesis.
- Prevention of nausea and vomiting associated with chemotherapy, radiation therapy, or surgery.
Who Shouldn't Take Gimoti?
- Hypersensitivity: Known hypersensitivity to metoclopramide or any components of the formulation.
- Pheochromocytoma: Patients with this rare tumor of the adrenal gland should avoid use.
- Severe Gastrointestinal Obstruction: Risk of exacerbating conditions.
Advice From The Pharmacist
- How to Use: Follow the administration instructions carefully. Prime the nasal spray before the first use and use it as directed.
- Monitor Symptoms: Regularly assess the patient's symptoms and response to treatment. Report any severe side effects to the healthcare provider.
- Avoid Alcohol: Alcohol may increase the risk of central nervous system side effects.
Side Effects of Gimoti
Common Side Effects
- Nasal irritation or discomfort
- Headache
- Dizziness or drowsiness
- Fatigue
Uncommon/Severe Side Effects
- Tardive Dyskinesia: A potentially irreversible condition characterized by involuntary movements.
- Neuroleptic Malignant Syndrome: A rare but serious condition that may occur with metoclopramide use.
Risks and Warnings of Gimoti
- Long-Term Use: Avoid prolonged use of metoclopramide, especially in elderly patients or those with risk factors for tardive dyskinesia.
- Monitor for Symptoms: Patients should be monitored for signs of movement disorders and other serious side effects.
Interactions with Gimoti
Common Drug Interactions
- Drug Interactions: Inform your healthcare provider about all medications you are taking, particularly other CNS depressants, as they may enhance sedative effects.
- Food Interactions: No specific food interactions, but a balanced diet is encouraged for overall gastrointestinal health.
Alternatives to Gimoti
- Other Prokinetic Agents: Such as erythromycin or domperidone.
- Antiemetic Medications: Such as ondansetron for nausea and vomiting.
