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Galantamine Hydrobromide ER
Galantamine Hydrobromide ER (extended-release) is a cholinesterase inhibitor used for the treatment of mild to moderate Alzheimer’s disease and dementia associated with Parkinson's disease. This formulation allows for once-daily dosing, helping to improve patient adherence. By increasing levels of acetylcholine in the brain, galantamine helps to enhance cognitive function and slow the progression of symptoms associated with these conditions.
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Frequently Asked Questions
How long does it take for Galantamine ER to start working?
Some patients may notice improvements in cognitive function within a few weeks, but it can take several months to see the full benefits.
Can Galantamine ER be used with other Alzheimer's medications?
Yes, but always consult your healthcare provider before combining Galantamine with other medications to manage Alzheimer’s disease.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Are there any dietary restrictions while taking Galantamine ER?
There are no specific dietary restrictions, but it’s advisable to maintain a balanced diet and limit alcohol consumption.
What should I do if I experience severe side effects?
Contact your healthcare provider immediately if you experience any severe reactions, such as severe gastrointestinal symptoms or changes in heart rate.
Comprehensive Drug Guide
How Does Galantamine Hydrobromide ER Work?
Galantamine Hydrobromide ER works by selectively inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine in the brain. This inhibition increases acetylcholine levels, enhancing cholinergic neurotransmission, which is essential for memory and learning. The extended-release formulation allows for a gradual release of the medication throughout the day.
Common Dosages
Galantamine Hydrobromide ER is available in the following forms:
- Extended-release capsules: 8 mg, 16 mg, 24 mg
Typical Dosing
The typical dosing for Galantamine Hydrobromide ER is:
- For Alzheimer’s Disease:
- Start with 8 mg taken once daily. After at least 4 weeks, the dose may be increased to 16 mg once daily based on tolerability. Further adjustments may lead to a maximum dose of 24 mg once daily.
Typical Dosing
FDA Approved Indications
- Treatment of mild to moderate Alzheimer’s disease.
- Management of dementia associated with Parkinson’s disease.
Who Shouldn't Take Galantamine Hydrobromide ER?
- Hypersensitivity: Known hypersensitivity to galantamine or any of its components.
- Severe Liver or Kidney Impairment: Use with caution in patients with severe hepatic or renal impairment.
Advice From The Pharmacist
- How to Take: Take Galantamine Hydrobromide ER once daily, preferably in the morning, with food to enhance absorption and minimize gastrointestinal side effects.
- Monitoring: Regularly monitor cognitive function and any side effects. Periodic assessment of kidney and liver function may also be necessary.
- Missed Dose: If a dose is missed, take it as soon as you remember on the same day. If it’s close to the next dose, skip the missed dose and return to your regular schedule.
Side Effects of Galantamine Hydrobromide ER
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions: Such as rash, itching, or swelling.
- Bradycardia: Slow heart rate, which may require monitoring.
Risks and Warnings of Galantamine Hydrobromide ER
- Suicidal Thoughts: Monitor for any increase in depressive symptoms or suicidal thoughts, particularly in younger patients.
- Cardiovascular Effects: Monitor for bradycardia and other cardiovascular issues, particularly in patients with pre-existing heart conditions.
- Gastrointestinal Side Effects: Monitor for gastrointestinal disturbances; may lead to dehydration in susceptible individuals.
Interactions with Galantamine Hydrobromide ER
Common Drug Interactions
- Drug Interactions: Galantamine Hydrobromide ER may interact with other medications, especially those affecting the metabolism of cholinergic drugs. Inform your healthcare provider about all medications you are taking.
- Food Interactions: Taking with food can help improve tolerability.
Alternatives to Galantamine Hydrobromide ER
- Other Cholinesterase Inhibitors: Donepezil (Aricept), Rivastigmine (Exelon).
- NMDA Receptor Antagonists: Memantine (Namenda) for moderate to severe Alzheimer's disease.
