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Exelon
Exelon (generic name: rivastigmine) is a cholinesterase inhibitor used to treat mild to moderate dementia associated with Alzheimer’s disease and Parkinson’s disease. It works by increasing the levels of acetylcholine in the brain, a neurotransmitter important for memory and cognition.
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Frequently Asked Questions
How long does it take for Exelon to work?
Improvements in cognition and behavior may be seen after a few weeks of consistent use.
Can Exelon cure Alzheimer’s disease?
No, Exelon does not cure Alzheimer’s disease. It helps manage symptoms and may slow the progression of cognitive decline.
Can I use Exelon if I have heart problems?
If you have a history of bradycardia or heart conditions, consult your healthcare provider before using Exelon, as it may slow your heart rate.
How should I store Exelon patches?
Store Exelon patches at room temperature. Keep them in their original packaging until ready to use.
Can Exelon be used long-term?
Yes, Exelon is often used as a long-term treatment for dementia, but regular monitoring by your healthcare provider is important to ensure it remains effective.
Comprehensive Drug Guide
How Does Exelon Work?
Exelon works by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine in the brain. By preventing the breakdown of acetylcholine, Exelon helps improve cognitive function in patients with dementia.
Common Dosages
- 1.5 mg, 3 mg, 4.5 mg, and 6 mg oral capsules
- 2 mg/mL oral solution
- 4.6 mg/24 hr, 9.5 mg/24 hr, and 13.3 mg/24 hr transdermal patch
Typical Dosing
- The typical starting dose is 1.5 mg twice daily (oral), which may be increased gradually. For the patch, the typical starting dose is 4.6 mg/24 hr, increased as needed.
Typical Dosing
FDA Approved Indications
- Mild to moderate dementia in patients with Alzheimer’s disease
- Mild to moderate dementia in patients with Parkinson’s disease
Who Shouldn't Take Exelon?
- Known hypersensitivity to rivastigmine or any other cholinesterase inhibitors.
Advice From The Pharmacist
- Take Exelon with food to minimize stomach upset.
- If using the patch, apply it to clean, dry skin on the upper back, chest, or arm. Replace the patch every 24 hours and avoid placing it on irritated skin.
- Do not cut the patch.
- Report any severe nausea, vomiting, or weight loss to your healthcare provider, as these may indicate side effects.
Side Effects of Exelon
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Dizziness
Uncommon/Severe Side Effects
- Severe skin reactions (with the patch)
- Bradycardia (slow heart rate)
Risks and Warnings of Exelon
- Gastrointestinal Issues: Exelon can cause severe nausea, vomiting, and weight loss, particularly when the dose is increased too quickly. Start at the lowest dose and increase gradually.
- Skin Reactions: The transdermal patch may cause skin irritation or allergic reactions. If you notice redness, swelling, or itching at the application site, discontinue the patch and contact your healthcare provider.
Interactions with Exelon
Common Drug Interactions
- Anticholinergic drugs: Medications that reduce acetylcholine activity (e.g., antihistamines) may counteract the effects of Exelon.
- Beta-blockers: Combining Exelon with beta-blockers may increase the risk of bradycardia (slow heart rate).
Alternatives to Exelon
- Donepezil (Aricept): Another cholinesterase inhibitor used to treat dementia.
- Galantamine (Razadyne): Another option for treating dementia associated with Alzheimer’s disease.
- Namenda (memantine): An NMDA receptor antagonist used in combination with cholinesterase inhibitors for moderate to severe Alzheimer’s.
