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Gablofen
Gablofen is an intrathecal baclofen used for treating severe muscle spasms related to multiple sclerosis and cerebral palsy. It works by relieving muscle spasms and offering pain relief allowing for better physical therapy. Common side effects include sedation, nausea, headache, and hypotonia but the benefits generally outweigh these effects.
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Frequently Asked Questions
Can Gablofen be used in children?
Yes, it is used in pediatric patients as well, but only under the close supervision of qualified healthcare professionals.
Can I stop Gablofen abruptly?
No, abrupt discontinuation can lead to several adverse reactions like hallucinations, seizures, and even death in severe cases.
What are the serious side effects of Gablofen?
Abrupt discontinuation of Gablofen can lead to dangerous adverse reactions. Other serious side effects include respiratory and cardiac failure leading to coma.
What if I missed a dose?
If you have missed a dose, take it as soon as you remember. But never double your dose.
Comprehensive Drug Guide
How Does Gablofen Work?
Gablofen is a GABAB receptor agonist that acts on the central nervous system to reduce muscle stiffness, improving voluntary movement.
What is Gablofen Used For?
FDA indications: Gablofen is used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
Offlabel uses: There are currently no recognized offlabel uses.
Common Dosages
Intrathecal: 125 mcg/mL suspension
Typical Dosing
FDA Approved Indications
- Spasticity: 50 mcg to 200 mcg per day by intrathecal infusion
Off-Label Uses
- No recognized offlabel uses to date
Who Shouldn't Take Gablofen?
- Patients are allergic to Gablofen or any of its ingredients.
- Patients with active infections near the intrathecal injection site.
- Patients with untreated epilepsy.
- Patients with other brain disorders.
Advice From The Pharmacist
- Do not abruptly discontinue Gablofen; abrupt withdrawal can lead to serious health complications.
- Always utilize the medication exactly as prescribed by a healthcare professional.
- Ensure that you keep your health provider informed about any changes in condition or adverse effects.
- Avoid alcohol and avoid engaging in activities requiring alertness as Gablofen may cause drowsiness.
Side Effects of Gablofen
Common Side Effects
- Common side effects: Sedation, nausea, headache, hypotonia.
Uncommon/Severe Side Effects
- Uncommon side effects: Dizziness, constipation, urinary retention, insomnia.
- Rare side effects: Seizures, hypothermia, suicide ideation.
- Severe side effects: Lifethreatening withdrawal symptoms, respiratory and cardiac failure, coma.
Risks and Warnings of Gablofen
- Gablofen carries a risk of serious adverse events including seizures, hallucinations, and death if the medication is abruptly discontinued.
- The medication carries a potential risk for CNS depression causing respiratory complications if not monitored properly.
- Gablofen can cause renal failure in patients with compromised renal function.
- Use with caution in patients with histories of stroke, respiratory diseases including COPD and pneumonia, and in elderly patients.
Interactions with Gablofen
Common Drug Interactions
- Antidepressants (like fluoxetine, and sertraline)
- Antihypertensives (like amlodipine, losartan)
- Antiepileptics (like phenytoin, and lamotrigine)
Alternatives to Gablofen
- Oral baclofen
- Tizanidine
- Diazepam
