Baclofen

Spasticity: Start with a low dose like 5mg three times per day. Your doctor will gradually increase your dose depending on your response and side effects.

For off-label uses:

• Alcohol withdrawal: 10 to 20mg taken three times a day.
• Trigeminal neuralgia: Depends on the severity of the condition and will be determined by the healthcare provider.

It's also been used for the off-label treatment of alcohol withdrawal syndrome, hiccups, and trigeminal neuralgia, among other conditions.

• Spasticity in children: The amount depends on the child’s body weight. It usually starts low, at 0.3 mg per kilogram of body weight per day. This dose is then increased by 15% each week until the desired effect is reached.
• Children under 12 years: not recommended.

• Have hypersensitivity to baclofen.
• Have a history of stroke, as it can exacerbate the symptoms.
• Certain types of mental disorders, like schizophrenia.
• Suffer from Parkinson's disease.
• Have renal impairment or a history of kidney disease.
• Are pregnant, planning to become pregnant, or are breastfeeding (it's not known whether baclofen harms the baby).
• Have epilepsy. Baclofen might increase the risk of seizures.

• Be cautious when driving or performing tasks that require alertness. Baclofen might make you feel drowsy or dizzy.
• Avoid alcohol while on baclofen. It can worsen the side effects like drowsiness and dizziness.
• Take this medication with food to avoid an upset stomach.
• If you've been taking baclofen for a while, don't stop abruptly. Your doctor will likely taper you off to avoid withdrawal symptoms.
• If you have kidney disease, your doctor might adjust your dose.

• You might feel drowsy, tired, or dizzy.
• You might have a headache or feel confused.
• You might feel shaky or weak.
• You might have trouble sleeping or have unusual dreams.

• You might have a rash or itching.
• You might have frequent urination or trouble urinating.
• You might have shallow breathing.
• You may hallucinate (see or hear things that aren't there).
• You might feel unusually restless or excited.
• Signs of a serious allergic reaction like rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing need immediate medical attention.

• Remember that Baclofen is not for everyone. It can lead to troubling side effects in certain situations and is not recommended if you have hypersensitivity to baclofen, a history of stroke, certain types of mental disorders, or Parkinson's disease.
• Baclofen should be used with caution in individuals with renal impairment or a history of kidney disease. Your physician might adjust the dose of the drug.
• If you suffer from epilepsy, baclofen might escalate the risk of seizures.
• Pregnancy and breastfeeding add a layer of caution. The effects of Baclofen on the infant aren’t clear, hence you must talk this through with a healthcare provider.
• Increased caution exists for those dealing with mental health issues - Baclofen may potentially trigger or worsen these conditions.

• Alcohol
• Antihistamines (like diphenhydramine, cetirizine)
• Sedatives (like zolpidem, alprazolam)
• Opioids (like hydrocodone, oxycodone)
• Antipsychotics (like haloperidol, risperidone)

• Baclofen and alcohol should not be used at the same time due to potential additive side effects, including dizziness, drowsiness, or difficulty concentrating.

• Tizanidine
• Cyclobenzaprine
• Carisoprodol
• Methocarbamol
• Dantrolene