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Fosrenol
Fosrenol (lanthanum carbonate) is a phosphate binder used to manage hyperphosphatemia (high phosphate levels) in patients with chronic kidney disease (CKD), particularly those on dialysis. It helps reduce phosphate levels in the blood by binding to phosphate in the diet and preventing its absorption. Fosrenol is typically used as part of a comprehensive treatment plan to manage kidney disease and prevent complications associated with high phosphate levels.
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Frequently Asked Questions
How long does it take for Fosrenol to work?
Fosrenol starts to work immediately upon ingestion, but it may take several weeks to see significant changes in phosphate levels.
Can Fosrenol be used if I have a history of bowel issues?
If you have a history of severe gastrointestinal conditions, consult your healthcare provider before using Fosrenol. They may recommend an alternative treatment.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Do not double up to make up for a missed dose.
Are there any specific dietary restrictions while taking Fosrenol?
Fosrenol should be taken with meals, and it is important to follow your healthcare provider’s dietary recommendations to manage phosphate levels effectively.
Comprehensive Drug Guide
How Does Fosrenol Work?
Fosrenol works by binding to dietary phosphate in the gastrointestinal tract. The lanthanum carbonate in Fosrenol reacts with phosphate in the diet to form an insoluble complex that is then excreted in the feces. This process helps lower the phosphate levels in the blood by preventing phosphate absorption from the diet.
What is Fosrenol Used For?
FDA indications: Lanthanum is used to control phosphorus levels in adults with chronic kidney disease who are on dialysis.
Common Dosages
- Chewable tablets: 500 mg, 750 mg, 1000 mg
Typical Dosing
The typical dosing for Fosrenol is:
- For Hyperphosphatemia: The usual starting dose is 1500 mg to 3000 mg per day, divided into three doses taken with meals. The dose may be adjusted based on phosphate levels and patient response.
Typical Dosing
FDA Approved Indications
- Hyperphosphatemia (high phosphate levels) in patients with chronic kidney disease (CKD), including those undergoing dialysis.
Who Shouldn't Take Fosrenol?
- Hypersensitivity: Patients with a known hypersensitivity to lanthanum carbonate or any of its components.
- Severe gastrointestinal conditions: Such as bowel obstruction or severe constipation.
Advice From The Pharmacist
- How to Take: Fosrenol should be chewed thoroughly before swallowing. It should be taken with meals to ensure effective phosphate binding.
- Interactions with Food/Alcohol: There are no specific interactions with food or alcohol, but it is important to take Fosrenol with food to maximize its effectiveness.
- When to Contact a Healthcare Provider: Contact your healthcare provider if you experience severe gastrointestinal symptoms, any signs of an allergic reaction, or if your phosphate levels remain high despite treatment.
Side Effects of Fosrenol
Common Side Effects
- Gastrointestinal discomfort (e.g., nausea, constipation, diarrhea)
- Abdominal pain
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., rash, itching, swelling)
- Severe gastrointestinal issues (e.g., persistent constipation or abdominal pain)
Risks and Warnings of Fosrenol
- Gastrointestinal Issues: Fosrenol can cause gastrointestinal symptoms such as constipation, which may be severe in some cases. It is important to monitor bowel movements and seek medical advice if severe symptoms occur.
- Allergic Reactions: Watch for signs of severe allergic reactions. Discontinue use and seek medical attention if such symptoms arise.
Interactions with Fosrenol
Common Drug Interactions
- Antacids: May interact with other medications that affect gastrointestinal pH.
- Iron Supplements: Can potentially reduce the absorption of iron.
Common Food Interactions
Dietary Phosphate: Fosrenol should be taken with meals to bind dietary phosphate effectively.
Alternatives to Fosrenol
- Calcium Acetate (e.g., PhosLo)
- Sevelamer Carbonate (e.g., Renvela)
- Aluminum Hydroxide (e.g., AlternaGel)