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Fosamprenavir Calcium
Fosamprenavir Calcium is a prodrug of amprenavir, used as part of a combination antiretroviral therapy for the treatment of HIV-1 infection. It is a protease inhibitor that works by inhibiting the HIV protease enzyme, which is essential for the maturation of infectious HIV particles. By blocking this enzyme, Fosamprenavir helps reduce the viral load in the body and improve immune function.
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Frequently Asked Questions
How should I store Fosamprenavir Calcium?
Store at room temperature, away from light and moisture. Keep out of reach of children.
What should I do if I miss a dose?
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up on doses.
Can I drink alcohol while taking Fosamprenavir Calcium?
Moderate alcohol consumption is generally considered safe, but excessive alcohol may increase the risk of liver issues.
How long will I need to take Fosamprenavir Calcium?
The duration of treatment depends on individual circumstances and should be determined by your healthcare provider. Adherence to the prescribed regimen is crucial.
Are there any dietary restrictions?
There are no specific dietary restrictions, but it's important to follow your healthcare provider's advice regarding diet and drug interactions.
Comprehensive Drug Guide
How Does Fosamprenavir Calcium Work?
Fosamprenavir Calcium is converted in the body to amprenavir, which works by inhibiting the HIV-1 protease enzyme. This enzyme is necessary for the cleavage of viral polyproteins into functional proteins, which are essential for the assembly of new viral particles. By blocking this enzyme, Fosamprenavir prevents the production of mature, infectious HIV particles, helping to control the infection.
Common Dosages
- Oral tablets: 700 mg
Typical Dosing
The typical dosing for Fosamprenavir Calcium is:
- For HIV-1 Infection: The usual dose is 700 mg taken orally twice daily with food, or as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
Treatment of HIV-1 infection in combination with other antiretroviral agents in adults and pediatric patients.
Who Shouldn't Take Fosamprenavir Calcium?
- Hypersensitivity: Patients with a known hypersensitivity to fosamprenavir or amprenavir.
- Severe Liver Impairment: Patients with severe hepatic impairment.
- Drug Interactions: Patients taking medications that are contraindicated with protease inhibitors, such as certain antiarrhythmics, antihistamines, and other drugs that are metabolized by the liver.
Advice From The Pharmacist
- Administration: Take Fosamprenavir Calcium with food to enhance absorption and reduce gastrointestinal side effects.
- Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, as Fosamprenavir may interact with other drugs.
- Side Effects: Monitor for side effects such as gastrointestinal discomfort, rash, or liver enzyme changes, and report any unusual symptoms to your healthcare provider.
- Compliance: Adhere to the prescribed regimen strictly to maintain effectiveness and prevent resistance.
Side Effects of Fosamprenavir Calcium
Common Side Effects
- Gastrointestinal Issues: Nausea, diarrhea, abdominal pain.
- Rash: Mild to moderate rash.
- Liver Enzyme Changes: Elevated liver enzymes, which may require monitoring. Serious side effects may include:
- Allergic Reactions: Severe rash, difficulty breathing.
- Hepatotoxicity: Severe liver damage, jaundice.
- Drug Interactions: Significant interactions with other medications.
Risks and Warnings of Fosamprenavir Calcium
- Liver Issues: Regular monitoring of liver function is recommended due to the potential for liver toxicity.
- Drug Interactions: Be cautious of interactions with other medications and substances that may affect Fosamprenavir metabolism.
- Immune System Effects: Monitor for signs of immune reconstitution inflammatory syndrome (IRIS) in patients with advanced HIV.:eyes
Interactions with Fosamprenavir Calcium
Common Drug Interactions
- Antifungals: Certain antifungals like ketoconazole can increase Fosamprenavir levels.
- Anticoagulants: May interact with blood thinners like warfarin.
- Other Antiretrovirals: Use with other HIV medications may require dose adjustments.
- Food and Drink: Grapefruit juice may affect drug metabolism and should be avoided.
Alternatives to Fosamprenavir Calcium
- Other Protease Inhibitors: Ritonavir, saquinavir, lopinavir/ritonavir.
- Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): Efavirenz, nevirapine.
- Integrase Inhibitors: Raltegravir, elvitegravir.
