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Fluoroplex
Fluoroplex (generic name: fluorouracil) is a topical chemotherapy agent used to treat pre-cancerous skin conditions such as actinic keratosis and superficial basal cell carcinoma. Fluorouracil works by interfering with the growth of abnormal skin cells, leading to their destruction. It is typically applied directly to the affected skin areas to target damaged or pre-cancerous cells.
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Frequently Asked Questions
How long will it take for Fluoroplex to work?
Fluoroplex treatment typically lasts 2 to 6 weeks, but visible improvement may take longer. You may continue to see the effects for several weeks after completing treatment.
Can I use Fluoroplex for skin conditions other than actinic keratosis or basal cell carcinoma?
Fluoroplex is specifically prescribed for these conditions and should not be used for other skin issues unless directed by your healthcare provider.
What should I do if I miss a dose?
Apply the missed dose as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses.
How should I care for my skin during treatment?
You may use a gentle cleanser and moisturizer to care for your skin during treatment, but avoid applying them directly on the treated area unless advised by your doctor. Avoid sun exposure and use sunscreen.
When should I see my doctor during treatment?
Consult your healthcare provider if you experience severe skin reactions (such as blistering or ulceration) or if your symptoms do not improve after several weeks of treatment.
Comprehensive Drug Guide
How Does Fluoroplex Work?
Fluoroplex works by interfering with the DNA and RNA synthesis of rapidly growing cells, such as cancerous or pre-cancerous skin cells. By blocking the production of nucleotides, it causes abnormal cells to stop dividing and die. This process leads to the destruction of abnormal skin cells while sparing most normal skin cells.
Common Dosages
- For actinic keratosis: Apply a thin layer to the affected areas twice daily for 2 to 6 weeks, as directed by your healthcare provider.
- For superficial basal cell carcinoma: Treatment duration and application frequency may vary depending on the size and severity of the lesion. Always follow your healthcare provider’s instructions.
Typical Dosing
- For pre-cancerous skin lesions: Apply a thin layer to the affected areas twice a day. Treatment usually lasts 2 to 6 weeks, depending on how the skin responds.
- For superficial skin cancer: Apply as directed by your healthcare provider, usually twice daily for several weeks.
Typical Dosing
FDA Approved Indications
- Actinic keratosis (pre-cancerous skin lesions caused by sun damage).
- Superficial basal cell carcinoma (a form of skin cancer) in certain cases, when surgical options are not appropriate.
Who Shouldn't Take Fluoroplex?
- Hypersensitivity to fluorouracil or any other components of the cream.
- Dihydropyrimidine dehydrogenase (DPD) enzyme deficiency, a rare genetic condition that can increase the risk of severe toxicity from fluorouracil.
Advice From The Pharmacist
- Apply Fluoroplex only to the affected areas as directed by your doctor. Avoid applying to normal, healthy skin, as this can cause irritation.
- Avoid sun exposure during treatment, as the medication can make your skin more sensitive to sunlight. Use sunscreen and protective clothing when outdoors.
- Wash your hands thoroughly after applying the cream, and avoid contact with your eyes, nose, or mouth.
- Expect redness, peeling, and discomfort at the treatment site. This is a normal part of the treatment process as the damaged skin cells are destroyed.
- Do not use occlusive dressings or bandages unless instructed by your doctor, as this can increase absorption and risk of side effects.
Side Effects of Fluoroplex
Common Side Effects
- Redness, peeling, or crusting of the skin at the application site
- Burning, itching, or irritation
- Swelling or soreness
Uncommon/Severe Side Effects
- Severe skin reactions such as blistering, ulceration, or intense pain
- Allergic reactions including swelling, rash, or difficulty breathing (rare)
Risks and Warnings of Fluoroplex
- Skin Reactions: Fluoroplex is designed to cause inflammation and destruction of abnormal skin cells, which may result in significant redness, peeling, and discomfort. These reactions are expected but should be monitored closely.
- Sun Sensitivity: Avoid excessive sun exposure while using Fluoroplex, as the skin will be more sensitive to UV rays. Always use sunscreen and protective clothing.
- Systemic Absorption: Though rare, if applied over large areas or under occlusive dressings, Fluoroplex can be absorbed into the bloodstream, leading to side effects similar to systemic chemotherapy.
Interactions with Fluoroplex
Common Drug Interactions
- Other topical medications: Avoid using other topical products (such as moisturizers or corticosteroids) on the treated area without consulting your healthcare provider, as they may interfere with the effectiveness of Fluoroplex.
- Photosensitizing agents: Use caution with medications that increase sun sensitivity, as Fluoroplex already increases the skin’s susceptibility to sun damage.
Alternatives to Fluoroplex
- Efudex (Fluorouracil): Another topical fluorouracil used for similar indications like actinic keratosis and superficial basal cell carcinoma.
- Imiquimod (Aldara): A topical immune response modifier used for actinic keratosis, superficial basal cell carcinoma, and other skin conditions.
- Ingenol Mebutate (Picato): A topical treatment for actinic keratosis that works by inducing cell death in abnormal skin cells.
