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Fintepla
Fintepla (generic name: fenfluramine) is an anticonvulsant medication used to treat seizures associated with Dravet syndrome in patients aged 2 years and older. Fintepla works by affecting the release of serotonin, which helps to control seizures in patients with Dravet syndrome, a rare and severe form of epilepsy.
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Frequently Asked Questions
How quickly does Fintepla start working?
Fintepla may take a few weeks to show a noticeable reduction in seizure frequency.
Can Fintepla cause weight loss?
Yes, Fintepla can cause decreased appetite and weight loss, which may be significant, especially in children.
How is Fintepla different from other seizure medications?
Fintepla works by affecting serotonin levels, whereas many other anticonvulsants work on different neurotransmitter pathways.
Can Fintepla be used for other types of epilepsy?
Currently, Fintepla is only approved for Dravet syndrome. Its use in other types of epilepsy has not been widely studied.
How often do I need heart monitoring while on Fintepla?
Regular echocardiograms are required to monitor for heart-related side effects, usually every 6 months or as directed by your healthcare provider.
Comprehensive Drug Guide
How Does Fintepla Work?
Fintepla works by increasing serotonin levels in the brain, which helps to reduce seizure frequency. Its exact mechanism in controlling seizures is not fully understood but is thought to involve serotonergic activity and modulation of the excitatory signals in the brain.
Common Dosages
- 2.2 mg/mL oral solution
Typical Dosing
- The typical starting dose is 0.1 mg/kg twice daily, which may be gradually increased based on the patient's response and tolerance.
Typical Dosing
FDA Approved Indications
- Seizures associated with Dravet syndrome in patients aged 2 years and older
Who Shouldn't Take Fintepla?
- Pulmonary arterial hypertension
- Known hypersensitivity to fenfluramine or any other components of the formulation
Advice From The Pharmacist
- Fintepla is taken twice daily, with or without food.
- Regular monitoring of heart function with echocardiograms is required while using Fintepla, as it may affect the heart.
- Keep the medication in its original packaging and measure the dose using a syringe provided by your pharmacist.
Side Effects of Fintepla
Common Side Effects
- Decreased appetite
- Diarrhea
- Drowsiness
- Fatigue
Uncommon/Severe Side Effects
- Valvular heart disease
- Pulmonary arterial hypertension
Risks and Warnings of Fintepla
- Heart Problems: Fintepla can cause serious heart problems, including valvular heart disease and pulmonary arterial hypertension. Regular heart monitoring is required.
- Weight Loss: Fintepla can cause significant weight loss. Your healthcare provider will monitor your weight and growth, especially in children.
Interactions with Fintepla
Common Drug Interactions
- SSRIs: Combining Fintepla with other drugs that affect serotonin levels (like selective serotonin reuptake inhibitors) can increase the risk of serotonin syndrome.
- Stimulants: Use caution when combining with stimulant medications due to the risk of increased heart rate and blood pressure.
Alternatives to Fintepla
- Epidiolex (cannabidiol): Another medication used for treating seizures associated with Dravet syndrome.
- Diacomit (stiripentol): An anticonvulsant used to treat seizures in Dravet syndrome.
- Topamax (topiramate): A broad-spectrum anticonvulsant used for treating epilepsy.
