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Felodipine ER
Felodipine ER (extended-release) is a calcium channel blocker used to treat high blood pressure (hypertension). It helps relax blood vessels so that blood can flow more easily, which lowers blood pressure and reduces the risk of stroke, heart attack, and other cardiovascular complications. Felodipine ER is a long-acting medication, meaning it releases the active ingredient gradually over time to provide a consistent effect throughout the day.
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Frequently Asked Questions
How long does it take for Felodipine ER to work?
Felodipine ER begins working within a few hours, but it may take 2 weeks or more to see the full effect on blood pressure. Continue taking the medication as prescribed even if you don’t see immediate results.
Can I take Felodipine ER with other blood pressure medications?
Yes, felodipine can be taken with other blood pressure medications like ACE inhibitors, beta-blockers, or diuretics. However, your healthcare provider will adjust the doses carefully to avoid excessively low blood pressure.
What should I do if I miss a dose of Felodipine ER?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for the missed one.
Can Felodipine ER cause swelling in the feet or ankles?
Yes, peripheral edema (swelling of the feet or ankles) is a common side effect of felodipine. If the swelling becomes severe or uncomfortable, contact your healthcare provider, as you may need a dose adjustment.
Is Felodipine ER safe for long-term use?
Yes, Felodipine ER is commonly used for long-term management of high blood pressure. However, regular monitoring of blood pressure and side effects is necessary to ensure the medication remains safe and effective over time.
Comprehensive Drug Guide
How Does Felodipine ER Work?
Felodipine works by inhibiting the influx of calcium ions into the smooth muscle cells of the blood vessels, particularly in the arteries. By reducing calcium entry, it causes the blood vessels to relax and widen (vasodilation), which leads to lower blood pressure. Felodipine ER specifically targets the arterial smooth muscle, making it more effective in controlling blood pressure without significantly affecting the heart rate.
What is Felodipine ER Used For?
- Hypertension: Used to manage high blood pressure, which helps prevent complications such as stroke, heart attack, and kidney disease.
Common Dosages
The typical dosage for Felodipine ER depends on the patient’s condition and response to treatment:
- Initial dose: 5 mg once daily.
- Maintenance dose: Can be adjusted to 2.5 mg to 10 mg once daily, based on the patient’s blood pressure response.
Typical Dosing
- For hypertension: The usual starting dose is 5 mg once daily, with adjustments made every 2 weeks as necessary. The dose can range from 2.5 mg to 10 mg once daily depending on the patient’s blood pressure response.
- Take Felodipine ER at the same time each day for consistent blood pressure control. Do not crush, chew, or split the extended-release tablets.
Typical Dosing
FDA Approved Indications
Hypertension: The initial recommended dose is 2.5 mg daily. Depending on your response, your doctor may gradually increase your dose.
Who Shouldn't Take Felodipine ER?
- Known hypersensitivity to felodipine or any components of the formulation.
- Severe hypotension (low blood pressure), as it may further lower blood pressure.
Advice From The Pharmacist
- Take Felodipine ER at the same time each day, preferably in the morning, with or without food. Avoid grapefruit juice, as it can increase the levels of felodipine in your bloodstream and lead to side effects.
- Do not crush or chew the tablets, as this will affect the extended-release mechanism and could release too much medication at once.
- If you experience dizziness or lightheadedness, especially when first starting the medication or increasing the dose, take caution when standing up from a sitting or lying position.
- Felodipine may cause swelling of the ankles or feet (edema). Contact your healthcare provider if swelling becomes severe.
- Continue taking Felodipine ER even if you feel well. High blood pressure often has no symptoms, so regular monitoring is essential to ensure it stays under control.
Side Effects of Felodipine ER
Common Side Effects
- Headache
- Flushing (warmth or redness in the face)
- Dizziness
- Swelling of the ankles or feet (peripheral edema)
- Fatigue
Uncommon/Severe Side Effects
- Severe hypotension (very low blood pressure), leading to dizziness, fainting, or weakness.
- Heart palpitations or irregular heartbeat.
- Gingival hyperplasia (overgrowth of the gums).
Risks and Warnings of Felodipine ER
- Hypotension: Felodipine ER can cause low blood pressure, especially when starting the medication or adjusting the dose. Patients should be monitored for symptoms of hypotension, such as dizziness or fainting.
- Peripheral Edema: Swelling of the ankles or feet is a common side effect of calcium channel blockers like felodipine. While usually mild, severe swelling may require dose adjustment or discontinuation.
- Gum Overgrowth (Gingival Hyperplasia): Long-term use of felodipine may cause gingival hyperplasia. Good oral hygiene and regular dental visits are recommended to minimize this risk.
Interactions with Felodipine ER
Common Drug Interactions
- Grapefruit juice: Increases the blood levels of felodipine, leading to a higher risk of side effects like hypotension and dizziness.
- Beta-blockers: Taking felodipine with beta-blockers (e.g., metoprolol) may increase the risk of low blood pressure and heart rate issues.
- CYP3A4 inhibitors: Drugs like ketoconazole, erythromycin, and diltiazem can increase felodipine levels, leading to an increased risk of side effects.
- CYP3A4 inducers: Drugs such as rifampin and phenytoin may reduce the effectiveness of felodipine by lowering its blood levels.
Alternatives to Felodipine ER
- Amlodipine (Norvasc): Another calcium channel blocker used for high blood pressure and angina.
- Nifedipine (Procardia): A calcium channel blocker with a similar mechanism but may offer different side effect profiles.
- Lisinopril (Zestril): An ACE inhibitor often used for high blood pressure and heart failure.
- Losartan (Cozaar): An angiotensin II receptor blocker (ARB) used for hypertension and kidney protection in diabetic patients.
