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Edurant
Edurant (rilpivirine) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretroviral agents to treat HIV-1 infection in adults and children aged 12 years and older. It helps to control HIV, allowing patients to live healthier lives and reducing the risk of HIV transmission. Edurant works by inhibiting the action of reverse transcriptase, an enzyme necessary for HIV replication, thereby reducing the amount of virus in the body.
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Frequently Asked Questions
How long does it take for Edurant to start working?
Edurant starts working right away to inhibit HIV replication, but it may take several weeks to see a significant reduction in viral load. Regular blood tests will be conducted to monitor progress.
Can Edurant cure HIV?
No, Edurant does not cure HIV. However, it helps control the virus, allowing patients to live longer, healthier lives while reducing the risk of transmission.
What should I do if I miss a dose of Edurant?
If you miss a dose and it has been less than 12 hours since the missed dose, take it as soon as possible with a meal. If more than 12 hours have passed, skip the missed dose and take your next dose at the regular time. Do not double up on doses.
Can I take Edurant with other HIV medications?
Yes, Edurant is always used in combination with other antiretroviral medications as part of a treatment regimen for HIV. Your healthcare provider will determine the best combination for you.
Is Edurant safe during pregnancy?
Edurant can be used during pregnancy if the potential benefits outweigh the risks. Consult with your doctor if you are pregnant or planning to become pregnant while on Edurant.
Comprehensive Drug Guide
How Does Edurant Work?
Edurant works by blocking the activity of reverse transcriptase, an enzyme used by HIV to convert its RNA into DNA, a critical step in the HIV replication process. By inhibiting this enzyme, Edurant prevents the virus from multiplying and helps reduce the viral load in the body.
Common Dosages
- Tablets: 25 mg
Typical Dosing
- For HIV treatment: The usual dose is 25 mg taken once daily with a meal. Edurant must be used in combination with other antiretroviral medications as part of an HIV treatment regimen.
Typical Dosing
FDA Approved Indications
HIV-1 infection in combination with other antiretroviral agents in treatment-naive adults and pediatric patients aged 12 years and older with a viral load of ≤100,000 copies/mL.
Who Shouldn't Take Edurant?
- Known hypersensitivity to rilpivirine or any component of the formulation
- Concurrent use of certain medications, such as anticonvulsants, proton pump inhibitors (PPIs), or rifampin, which can reduce the effectiveness of Edurant.
Advice From The Pharmacist
- Take Edurant exactly as prescribed, once daily with a meal to improve absorption.
- Do not skip doses, as doing so can increase the risk of HIV developing resistance to the medication.
- Edurant may interact with other medications, including antacids and H2-receptor antagonists, so take these medications at least 2 hours before or 4 hours after Edurant.
- Continue taking Edurant even if you feel well. Stopping the medication can lead to an increase in your viral load.
Side Effects of Edurant
Common Side Effects
- Depression
- Insomnia
- Headache
- Rash
Uncommon/Severe Side Effects
- Severe skin reactions (rash with fever, blistering)
- Mood changes or worsening depression
- Liver problems (yellowing of the skin or eyes)
Risks and Warnings of Edurant
- Depression and Mood Changes: Edurant may cause or worsen depression and mood changes. Patients should be monitored for signs of depression or suicidal thoughts, especially during the early stages of treatment.
- Liver Health: Edurant can cause liver problems, especially in patients with hepatitis B or C co-infections. Regular liver function monitoring is recommended.
- Drug Interactions: Edurant has significant interactions with certain medications, including anticonvulsants and antacids, which can decrease its effectiveness. Always inform your healthcare provider of all medications you are taking.
Interactions with Edurant
Common Drug Interactions
- Proton pump inhibitors (PPIs): Medications like omeprazole can significantly reduce the absorption of Edurant and should be avoided.
- Antacids: These can reduce the effectiveness of Edurant if taken too close to the dose. Space antacids at least 2 hours before or 4 hours after taking Edurant.
- Rifampin: This antibiotic can decrease the levels of Edurant, making it less effective.
Alternatives to Edurant
- Efavirenz (Sustiva): Another NNRTI used in combination with other antiretroviral agents to treat HIV.
- Dolutegravir (Tivicay): An integrase inhibitor used for HIV treatment.
- Bictegravir/emtricitabine/tenofovir (Biktarvy): A single-tablet regimen combining multiple antiretrovirals.
