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Edecrin
Edecrin (ethacrynic acid) is a loop diuretic used to treat edema (fluid retention) associated with conditions such as heart failure, kidney disease, and liver cirrhosis. By promoting the removal of excess water and salt from the body through the urine, Edecrin helps to reduce swelling and improve symptoms of fluid overload. It is especially useful for patients who cannot tolerate other diuretics like furosemide.
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Frequently Asked Questions
How long does it take for Edecrin to start working?
Edecrin typically begins working within 30 to 60 minutes after taking the oral form, and within minutes after receiving the intravenous form.
Can I take Edecrin with food?
Yes, Edecrin can be taken with or without food. If you experience stomach upset, taking it with food may help reduce discomfort.
What should I do if I miss a dose of Edecrin?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and take the next one as scheduled. Do not double up on doses.
Can Edecrin cause hearing loss?
Yes, Edecrin can cause hearing problems, including hearing loss, especially at high doses or when used with other ototoxic medications. Contact your healthcare provider if you experience ringing in the ears or hearing difficulties.
Is Edecrin safe for long-term use?
Edecrin can be used long-term under careful medical supervision, with regular monitoring of kidney function, electrolytes, and hearing. Always follow your healthcare provider’s recommendations for ongoing use.
Comprehensive Drug Guide
How Does Edecrin Work?
Edecrin works by inhibiting the sodium-potassium-chloride cotransporter in the loop of Henle in the kidneys. This reduces the reabsorption of sodium, potassium, and chloride, leading to increased excretion of water and electrolytes, which decreases fluid accumulation in the body.
Common Dosages
- Tablets: 25 mg
- Intravenous solution: 50 mg/1 mL
Typical Dosing
- For edema: The typical starting dose is 50 mg to 200 mg per day, divided into smaller doses. For more severe cases, the dose may be increased based on response and the patient’s condition. For IV use, the dosing is individualized based on the clinical setting.
Typical Dosing
FDA Approved Indications
- Edema associated with heart failure, liver disease, or kidney disease
- Edema in patients who are resistant to or intolerant of other diuretics
Who Shouldn't Take Edecrin?
- Known hypersensitivity to ethacrynic acid
- Severe electrolyte imbalances
- Anuria (inability to produce urine)
Advice From The Pharmacist
- Take Edecrin exactly as prescribed, and be sure to follow any specific instructions regarding fluid and electrolyte monitoring.
- It is important to stay hydrated while taking Edecrin, but consult your healthcare provider about the appropriate amount of fluid intake.
- Edecrin may cause increased urination, so it is best to take it earlier in the day to avoid frequent nighttime urination.
- Monitor for signs of dehydration, such as dry mouth, dizziness, and low blood pressure, and seek medical advice if these symptoms occur.
Side Effects of Edecrin
Common Side Effects
- Increased urination
- Dizziness
- Low blood pressure (hypotension)
- Nausea
Uncommon/Severe Side Effects
- Electrolyte imbalances (low potassium, sodium, or magnesium levels)
- Ototoxicity (hearing problems, ringing in the ears)
- Severe dehydration
Risks and Warnings of Edecrin
- Ototoxicity: Edecrin can cause hearing loss or ringing in the ears (tinnitus), especially when used in high doses or in combination with other ototoxic drugs.
- Electrolyte Imbalances: Edecrin can cause significant electrolyte imbalances, including low levels of potassium, sodium, and magnesium. Regular monitoring of electrolytes is recommended during treatment.
- Dehydration: Excessive fluid loss can lead to dehydration, which may result in low blood pressure, dizziness, or fainting.
Interactions with Edecrin
Common Drug Interactions
- Digoxin: Combining Edecrin with digoxin may increase the risk of digoxin toxicity due to low potassium levels.
- NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the effectiveness of Edecrin and increase the risk of kidney problems.
- Aminoglycoside antibiotics: These antibiotics may increase the risk of hearing loss when used with Edecrin.
Alternatives to Edecrin
- Furosemide (Lasix): Another loop diuretic commonly used to treat edema, though some patients may not tolerate it as well as Edecrin.
- Bumetanide (Bumex): A potent loop diuretic used for similar indications.
- Spironolactone (Aldactone): A potassium-sparing diuretic used for edema, often in combination with other diuretics to prevent potassium loss.
