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Diflunisal
Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, tenderness, swelling, and stiffness in individuals with ailments such as osteoarthritis and rheumatoid arthritis. The medication works by inhibiting the body from producing substances that cause inflammation and pain.
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Frequently Asked Questions
Can I take Diflunisal if I am pregnant or breastfeeding?
Diflunisal should be avoided during the third trimester of pregnancy as it might affect the fetal heart. The safety of use during breastfeeding is not established, so it's better to consult your healthcare provider.
Does Diflunisal cause weight gain?
Weight gain is not listed as a side effect of Diflunisal, but if you notice any unusual weight changes, inform your healthcare provider.
What if I miss a dose of Diflunisal?
Take the dose as soon as you remember, unless it's too close to the next one. Don't double up your dose if you've missed one.
Can I just stop taking Diflunisal after my symptoms are relieved?
Always consult with your healthcare provider before changing your dosing regimen. Although not typical for NSAIDs, abrupt discontinuation could have possible effects.
Comprehensive Drug Guide
How Does Diflunisal Work?
Diflunisal is a salicylate derivative that works by inhibiting cyclooxygenase-2 (the enzyme responsible for inflammation) in the body. The result massively reduces prostaglandin synthesis responsible for inflammation and pain.
What is Diflunisal Used For?
FDA indications: Diflunisal is utilized to treat mild to moderate pain and chronic joint inflammation in conditions like osteoarthritis and rheumatoid arthritis.
Common Dosages
Tablets: 500mg
Typical Dosing
FDA Approved Indications
- Adults: Initially, 1000mg as a first dose, thereafter 500mg every 12 hours. If needed, doses may be increased to 1000mg every 12 hours.
Off-Label Uses
- Pediatric use: Safety and effectiveness in pediatric patients have not been established.
Who Shouldn't Take Diflunisal?
- Individuals with known hypersensitivity to Diflunisal or other NSAIDs
- People who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or NSAIDs
- Patients with the triad of asthma, recurrent nasal polyps, and paranasal sinus inflammation.
- Patients with known heart disease or risk factors for heart disease.
- Individuals with a history of peptic ulcer or gastrointestinal bleeding
Advice From The Pharmacist
- - Diflunisal should be taken with food or milk to prevent an upset stomach.
- - Avoid alcohol while taking Diflunisal as it can increase the risk of gastric ulcers.
- - Stay away from aspirin or other NSAIDs while on Diflunisal unless your doctor advises otherwise.
- - Avoid lying down for at least 10 minutes after taking this drug.
- - Pregnant women should not use Diflunisal, especially in their last trimester unless specifically advised by the doctor due to possible harm to the unborn baby
- - Just like with any other NSAID, long-term use can lead to kidney and/or liver damage.
Side Effects of Diflunisal
Common Side Effects
- - Common side effects: nausea, dyspepsia, and skin rashes.
Uncommon/Severe Side Effects
- - Uncommon side effects: tinnitus, blurred vision, diarrhea, and dizziness.
- - Rare side effects: interstitial nephritis, hepatitis, pulmonary hypersensitivity.
Risks and Warnings of Diflunisal
- Diflunisal can increase the risk of a fatal heart attack or stroke, particularly if you use it for a long time or have heart disease.
- Diflunisal may cause ulcers, bleeding, or holes in the stomach or small intestine, leading to related symptoms like stomach pain, heartburn, and vomit looking like coffee grounds.
- Diflunisal should be avoided in late pregnancy due to the risk of premature closure of the ductus arteriosus in the fetus.
- Just like other NSAIDs, Diflunisal can cause serious skin conditions like Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms.
Interactions with Diflunisal
Common Drug Interactions
- Coumarin-type anticoagulants
- Other NSAIDs (including aspirin)
- Oral hypoglycemics
- ACE inhibitors
- Diuretics
- Methotrexate
Alternatives to Diflunisal
- Ibuprofen
- Naproxen
- Ketoprofen
- Meloxicam
- Celecoxib
