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Diclegis
Diclegis (generic name: doxylamine succinate and pyridoxine hydrochloride) is a prescription medication used to treat nausea and vomiting during pregnancy (morning sickness). It is a combination of doxylamine, an antihistamine, and pyridoxine (vitamin B6), which helps manage nausea. Diclegis is generally recommended for pregnant women when dietary and lifestyle changes fail to relieve symptoms.
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Frequently Asked Questions
How long does it take for Diclegis to work?
Diclegis usually begins to relieve nausea symptoms within 1 to 2 days of starting treatment.
Can I take Diclegis throughout my pregnancy?
Yes, Diclegis is considered safe for long-term use during pregnancy to manage nausea, but you should always consult with your healthcare provider.
What should I do if Diclegis doesn’t relieve my nausea?
If Diclegis does not adequately relieve your symptoms, talk to your healthcare provider about adjusting the dosage or trying other treatment options.
Can Diclegis cause birth defects?
Diclegis has been studied extensively and is generally considered safe for use during pregnancy, with no increased risk of birth defects.
Can I stop taking Diclegis suddenly?
Yes, Diclegis can be stopped when symptoms improve. However, consult your doctor before making any changes to your treatment plan.
Comprehensive Drug Guide
How Does Diclegis Work?
The exact mechanism by which Diclegis reduces nausea and vomiting is not fully understood. Doxylamine is an antihistamine that blocks histamine H1 receptors, which may help reduce nausea. Pyridoxine (vitamin B6) is thought to play a role in reducing nausea by influencing neurotransmitter activity in the brain.
Common Dosages
- Diclegis is available as 10 mg doxylamine succinate and 10 mg pyridoxine hydrochloride in delayed-release tablets.
Typical Dosing
- For nausea and vomiting during pregnancy: Start with two tablets at bedtime. If symptoms persist, the dose can be increased to one tablet in the morning and two at bedtime, or as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Nausea and vomiting of pregnancy (morning sickness) in women who do not respond to dietary or lifestyle changes.
Who Shouldn't Take Diclegis?
- Known hypersensitivity to doxylamine, pyridoxine, or any of the ingredients.
- MAOI (monoamine oxidase inhibitors) use, as it may lead to serious interactions.
Advice From The Pharmacist
- Take Diclegis on an empty stomach with a glass of water.
- Diclegis can cause drowsiness. Avoid driving or operating heavy machinery until you know how the medication affects you.
- If you miss a dose, take it as soon as you remember. If it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Side Effects of Diclegis
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Confusion or disorientation
Risks and Warnings of Diclegis
- Drowsiness: Diclegis may cause significant drowsiness, so caution should be exercised when performing activities that require alertness.
- Alcohol use: Avoid alcohol while taking Diclegis, as it can increase the sedative effects of the medication.
Interactions with Diclegis
Common Drug Interactions
- CNS depressants (such as benzodiazepines, opioids, or alcohol) can increase the risk of drowsiness and sedation when taken with Diclegis.
- MAO inhibitors: Taking Diclegis with MAOIs can result in serious interactions.
Alternatives to Diclegis
- Unisom and Vitamin B6: Over-the-counter versions of doxylamine and vitamin B6 may be used to treat morning sickness in some cases.
- Zofran (ondansetron): A prescription anti-nausea medication used in pregnancy when Diclegis is not effective.
- Phenergan (promethazine): Another prescription antihistamine used to manage nausea and vomiting.
