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Dexilant
Dexilant (dexlansoprazole) is a proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD), erosive esophagitis, and other conditions involving excess stomach acid. It works by reducing the amount of acid produced in the stomach, helping to relieve symptoms such as heartburn, difficulty swallowing, and persistent cough.
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Frequently Asked Questions
How long does it take for Dexilant to work?
Most people start to experience relief from heartburn and other symptoms within 1 to 2 days of starting Dexilant. However, it may take a few weeks for full healing of erosive esophagitis.
Can Dexilant be taken long-term?
Dexilant can be used for long-term maintenance therapy, but long-term use may increase the risk of side effects, such as bone fractures and low magnesium levels. Regular monitoring by your healthcare provider is recommended.
What should I do if I miss a dose of Dexilant?
Take the missed dose as soon as you remember. If it is close to your next dose, skip the missed dose and take the next one at the regular time. Do not double the dose.
Can Dexilant cause kidney problems?
Yes, in rare cases, PPIs like Dexilant can cause kidney problems, including acute interstitial nephritis. Contact your healthcare provider if you experience signs of kidney issues, such as decreased urination or swelling in the legs.
Is Dexilant safe during pregnancy?
Dexilant is classified as pregnancy category B, meaning it is generally considered safe to use during pregnancy. However, it’s important to discuss all medications with your healthcare provider during pregnancy.
Comprehensive Drug Guide
How Does Dexilant Work?
Dexilant works by inhibiting the proton pump in the stomach lining, which is responsible for secreting acid. By blocking this pump, Dexilant reduces the production of stomach acid, allowing the esophagus and stomach to heal from acid damage and reducing symptoms of heartburn.
Common Dosages
- Delayed-release capsules: 30 mg, 60 mg.
Typical Dosing
- For GERD: The typical dose is 30 mg once daily for 4 to 8 weeks.
- For erosive esophagitis: The dose is 60 mg once daily for up to 8 weeks, followed by 30 mg once daily for maintenance.
Typical Dosing
FDA Approved Indications
- Gastroesophageal reflux disease (GERD).
- Erosive esophagitis (healing and maintenance).
- Heartburn associated with excess stomach acid.
Who Shouldn't Take Dexilant?
- Known hypersensitivity to dexlansoprazole or any component of the formulation.
- Individuals with a history of allergic reactions to other PPIs.
Advice From The Pharmacist
- Take Dexilant once daily with or without food. Swallow the capsule whole; do not crush or chew it.
- If you have trouble swallowing the capsule, you may open it and sprinkle the contents on applesauce, but be sure to swallow the mixture without chewing.
- Contact your healthcare provider if your symptoms do not improve after a few weeks of treatment.
Side Effects of Dexilant
Common Side Effects
- Diarrhea
- Nausea
- Headache
- Stomach pain
- Gas
Uncommon/Severe Side Effects
- Bone fractures (with long-term use)
- Kidney problems
- Low magnesium levels
Risks and Warnings of Dexilant
- Bone Fractures: Long-term use of PPIs like Dexilant has been associated with an increased risk of fractures, particularly in the hip, wrist, and spine. Use the lowest effective dose for the shortest duration necessary.
- Low Magnesium Levels: Dexilant can cause hypomagnesemia (low magnesium levels), especially with prolonged use. Symptoms may include muscle cramps, seizures, or abnormal heart rhythms.
- Clostridium difficile Infection: Use of PPIs may increase the risk of intestinal infections such as C. difficile, leading to diarrhea.
Interactions with Dexilant
Common Drug Interactions
- Clopidogrel (Plavix): Dexilant can reduce the effectiveness of clopidogrel, a blood thinner, increasing the risk of blood clots.
- Methotrexate: Dexilant may increase methotrexate levels in the blood, leading to toxicity.
- Antifungals: Drugs like ketoconazole may have reduced absorption when taken with Dexilant due to changes in stomach acidity.
Alternatives to Dexilant
- Prilosec (omeprazole): Another proton pump inhibitor used to treat GERD and other acid-related conditions.
- Protonix (pantoprazole): A PPI commonly used for the treatment of GERD and erosive esophagitis.
- Zantac (ranitidine): An H2 blocker that reduces stomach acid, though it is less potent than PPIs.
