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Dexlansoprazole
Dexlansoprazole is a proton pump inhibitor (PPI) used primarily for the treatment of gastroesophageal reflux disease (GERD) and other conditions where reduction of stomach acid can offer relief. Some common side effects include diarrhea, gas, and nausea, but your physician will always balance these against the aid the medication is providing.
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Frequently Asked Questions
Can I have alcohol with Dexlansoprazole?
Yes, but alcohol can worsen your condition if you're taking dexlansoprazole for GERD or similar issues. So, it's best to limit your alcohol intake.
Can I just stop taking Dexlansoprazole once my symptoms improve?
No, you should complete the course as prescribed by your doctor. Abrupt cessation can cause the symptoms to return or worsen.
Can I take Dexlansoprazole if I have liver problems?
Yes, but caution is advised and a lower dose may be required. Always consult with your healthcare provider first.
Does Dexlansoprazole interfere with my other medications?
It may. Dexlansoprazole can interact with certain other medicines. Always let your doctor know about all other medicines you're taking.
I missed a dose of Dexlansoprazole, what should I do?
Take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed dose. Never take double the dose to make up for the missed one.
Should I take the medicine before or after meals?
Dexlansoprazole should be taken before meals, at least 30 minutes prior.
Comprehensive Drug Guide
How Does Dexlansoprazole Work?
Dexlansoprazole is a proton pump inhibitor that suppresses gastric acid secretion by inhibiting the gastric H, KATPase at the secretory surface of the gastric parietal cell, by forming a covalent bond with the enzyme, effectively controlling acid reflux.
What is Dexlansoprazole Used For?
FDA indications: Dexlansoprazole is used to treat conditions like gastroesophageal reflux disease (GERD), erosive esophagitis (EE), and ZollingerEllison syndrome.
Offlabel uses: It's also prescribed for the offlabel treatment of peptic ulcer disease and prevention of nonsteroidal antiinflammatory drug (NSAID)induced gastric
Common Dosages
Capsules: 30mg, 60mg
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- GERD & EE: 60mg once daily for up to 8 weeks.
- Maintenance of healed EE: 30mg once daily.
- ZollingerEllison syndrome: dosage and duration will be determined by the healthcare provider.
Off-Label Uses
- For offlabel uses:
- Peptic ulcer disease: 30mg once daily for 48 weeks.
- NSAIDinduced ulcer prophylaxis: 30mg once daily.
Who Shouldn't Take Dexlansoprazole?
- Have a known hypersensitivity to the drug.
- Have a known hypersensitivity to any other component of the formulation.
- Have a known hypersensitivity to substituted benzimidazoles.
- Are taking rilpivirinecontaining products.
Advice From The Pharmacist
- Delayedrelease capsules should be swallowed whole alone or be opened and the contents sprinkled on a tablespoonful of applesauce.
- Dexlansoprazole should be taken at least 30 minutes before meals.
- Do not crush or chew this medication.
- Inform your physician if your symptoms continue or recur after completing your prescribed medication regimen.
- Do not discontinue use abruptly, follow the instruction of your healthcare provider.
- This medication is best taken in the morning.
Side Effects of Dexlansoprazole
Common Side Effects
- Diarrhea
- Gas
- Nausea
- Abdominal pain
Uncommon/Severe Side Effects
- Uncommon side effects:
- Vomiting
- Rare side effects:
- Allergic reactions, such as rash, face swelling, and breathing difficulty
- StevensJohnson Syndrome/Symptoms: fever, flulike symptoms, and a red/purplish rash that spreads.
- Severe side effects:
- Acute interstitial nephritis (sudden inflammation of the kidneys)
Risks and Warnings of Dexlansoprazole
- Patients are at risk of hip, wrist, and spine fractures on longterm acidreducing therapy. This risk is increased in older adults and patients receiving high doses or longterm therapy of PPIs (more than a year).
- Before starting treatment, risk vs. benefit assessment should be made for individuals at risk for osteoporosisrelated fractures who take multiple daily doses, and for long durations.
- Cutaneous and systemic lupus erythematosus have been reported with PPIs; avoid using PPIs for less serious conditions.
Interactions with Dexlansoprazole
Common Drug Interactions
- Methotrexate
- Warfarin
- Nelfinavir
- St. John's Wort
Alternatives to Dexlansoprazole
- Omeprazole
- Lansoprazole
- Esomeprazole
- Pantoprazole
- Rabeprazole
