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Delzicol
Delzicol (mesalamine) is an anti-inflammatory medication used to treat and maintain remission in patients with ulcerative colitis, a chronic inflammatory bowel disease (IBD). Mesalamine helps reduce inflammation in the colon and rectum, easing symptoms such as diarrhea, rectal bleeding, and abdominal pain. Delzicol is designed to release mesalamine directly into the lower intestine, where it works to reduce inflammation.
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Frequently Asked Questions
How long does it take for Delzicol to work?
Delzicol may start reducing symptoms of ulcerative colitis within a few days, but full benefits may take up to 6 weeks of consistent use.
Can Delzicol be used for Crohn’s disease?
Delzicol is specifically indicated for ulcerative colitis, but other mesalamine formulations like Pentasa may be used for Crohn’s disease. Consult your healthcare provider for appropriate treatment.
What should I do if I miss a dose of Delzicol?
Take the missed dose as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses.
Can I take Delzicol during pregnancy?
Delzicol is classified as pregnancy category B, meaning it is generally considered safe for use during pregnancy. However, always consult your healthcare provider before starting any new medication during pregnancy.
Is Delzicol safe for long-term use?
Yes, Delzicol is often used for long-term maintenance of ulcerative colitis remission. Regular monitoring of kidney and liver function is recommended during long-term treatment.
Comprehensive Drug Guide
How Does Delzicol Work?
Delzicol works by releasing mesalamine, which reduces inflammation by inhibiting the production of inflammatory mediators in the colon and rectum. This helps alleviate symptoms of ulcerative colitis and maintain remission.
Common Dosages
- Delayed-release capsules: 400 mg of mesalamine.
Typical Dosing
- For acute treatment of ulcerative colitis: The typical dose is 800 mg (two capsules) taken three times daily for 6 weeks.
- For maintenance of remission: The usual dose is 1.6 grams (four capsules) taken daily in divided doses.
Typical Dosing
FDA Approved Indications
- Mild to moderate ulcerative colitis.
- Maintenance of remission of ulcerative colitis.
Who Shouldn't Take Delzicol?
- Known hypersensitivity to mesalamine or salicylates (e.g., aspirin).
- Severe liver or kidney impairment.
Advice From The Pharmacist
- Take Delzicol with or without food. Swallow the capsules whole; do not crush, chew, or break them, as they are designed to release the medication in the lower intestine.
- It is important to take Delzicol as prescribed, even if you feel well, to maintain remission of ulcerative colitis.
- If you experience worsening symptoms or side effects such as severe abdominal pain or bloody stools, contact your healthcare provider immediately.
Side Effects of Delzicol
Common Side Effects
- Nausea
- Headache
- Abdominal pain
- Diarrhea
- Gas or bloating
Uncommon/Severe Side Effects
- Kidney problems (nephrotoxicity)
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Liver function abnormalities
Risks and Warnings of Delzicol
- Kidney Toxicity: Mesalamine can cause kidney problems in some patients. Regular kidney function monitoring is recommended, especially for long-term use.
- Liver Impairment: Delzicol should be used with caution in patients with liver disease, and liver function should be monitored during treatment.
- Salicylate Sensitivity: Patients allergic to salicylates (e.g., aspirin) should avoid using Delzicol due to the risk of an allergic reaction.
Interactions with Delzicol
Common Drug Interactions
- NSAIDs (e.g., ibuprofen, naproxen) may increase the risk of kidney damage when taken with Delzicol.
- Azathioprine or 6-mercaptopurine: Combining these immunosuppressants with Delzicol can increase the risk of blood disorders (e.g., low white blood cell count).
Alternatives to Delzicol
- Asacol HD: Another delayed-release form of mesalamine for the treatment of ulcerative colitis.
- Lialda: An extended-release mesalamine tablet designed to deliver the medication throughout the colon for the treatment of ulcerative colitis.
- Pentasa: A mesalamine formulation used for both ulcerative colitis and Crohn’s disease.
