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Pentasa
Pentasa (mesalamine) is an anti-inflammatory medication primarily used for the treatment of ulcerative colitis and Crohn's disease. It works by reducing inflammation in the lining of the intestines, helping to alleviate symptoms and maintain remission in patients with inflammatory bowel disease (IBD).
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Frequently Asked Questions
How quickly does Pentasa work?
Patients may start to notice improvements in symptoms within a few weeks, but it may take longer for full effects, especially in chronic conditions.
Can I take Pentasa with food?
Yes, Pentasa can be taken with or without food, but consistency in how you take it is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is Pentasa safe during pregnancy?
Pentasa is generally considered safe during pregnancy, but consult your healthcare provider for personalized advice.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions, kidney issues, or worsening gastrointestinal symptoms, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Pentasa Work?
Pentasa works by directly acting on the colonic mucosa to inhibit the production of inflammatory mediators, thereby reducing inflammation and ulceration in the intestines. Its local action helps to control the symptoms associated with ulcerative colitis and Crohn's disease.
Common Dosages
Pentasa is typically available in the following forms:
- Extended-release tablets: Common strengths include 250 mg and 500 mg.
- Rectal suspension: 4 g/60 mL for local treatment of ulcerative colitis.
Typical Dosing
- Adults with Ulcerative Colitis: The usual starting dose is 2.4 g daily, taken in divided doses. Maintenance doses may vary based on clinical response.
- Adults with Crohn's Disease: The starting dose may be similar, and adjustments are made according to individual patient needs.
Typical Dosing
FDA Approved Indications
- Treatment of mild to moderate ulcerative colitis.
- Maintenance of remission in patients with ulcerative colitis.
- Treatment of Crohn's disease in patients with mild to moderate disease.
Who Shouldn't Take Pentasa?
- Known hypersensitivity to mesalamine or any component of the formulation
- Severe renal impairment
Advice From The Pharmacist
- Take Pentasa exactly as prescribed, and do not alter the dosage without consulting your healthcare provider.
- Drink plenty of fluids to help prevent dehydration, especially during flare-ups.
- Monitor for any side effects and report significant issues, such as abdominal pain or severe diarrhea, to your healthcare provider.
Side Effects of Pentasa
Common Side Effects
- Headache
- Nausea
- Abdominal pain
- Diarrhea
Uncommon/Severe Side Effects
- Pancreatitis
- Kidney problems (including interstitial nephritis)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Pentasa
- Renal Function: Monitor kidney function regularly, especially in patients with a history of kidney disease.
- Blood Dyscrasias: Be alert for signs of blood disorders, such as unusual bruising or bleeding, and report these to your healthcare provider.
Interactions with Pentasa
Common Drug Interactions
Other Medications: Inform your healthcare provider about all medications you are taking, as certain drugs may interact with mesalamine, particularly those affecting renal function.
Alternatives to Pentasa
- Other 5-ASA Compounds: Such as sulfasalazine or balsalazide for similar indications.
- Corticosteroids: For more severe cases of inflammatory bowel disease.
