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Cosopt PF
Cosopt PF is a combination ophthalmic solution used to reduce elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It contains two active ingredients: dorzolamide, a carbonic anhydrase inhibitor, and timolol, a beta-blocker. Together, these components reduce fluid production in the eye and promote drainage, helping to lower pressure and prevent optic nerve damage. Cosopt PF (preservative-free) is specially formulated for patients who may be sensitive to preservatives found in other eye drops.
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Frequently Asked Questions
How long does it take for Cosopt PF to start working?
Cosopt PF typically begins to reduce intraocular pressure within a few hours of application, but it may take several weeks to achieve the full effect.
Can I use Cosopt PF if I wear contact lenses?
You should remove contact lenses before applying Cosopt PF and wait at least 15 minutes after administration before reinserting them, as the solution can be absorbed by the lenses.
What should I do if I miss a dose of Cosopt PF?
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Cosopt PF during pregnancy?
Cosopt PF should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.
Can I use Cosopt PF with other glaucoma medications?
Yes, Cosopt PF can be used with other glaucoma medications, but make sure to wait at least 10 minutes between administering different eye drops to prevent dilution of the medications. Always follow your doctor's instructions.
Comprehensive Drug Guide
How Does Cosopt PF Work?
Cosopt PF works by combining two mechanisms:
- Dorzolamide reduces the production of fluid (aqueous humor) in the eye by inhibiting carbonic anhydrase, an enzyme involved in fluid regulation.
- Timolol reduces the production of aqueous humor by blocking beta-adrenergic receptors, which decreases intraocular pressure.
What is Cosopt PF Used For?
Open-angle glaucoma
Ocular hypertension
Common Dosages
Cosopt PF is available by prescription only as a sterile, preservative-free ophthalmic solution in single-use containers. It is not classified as a controlled substance.
- Each container delivers 2% dorzolamide and 0.5% timolol solution.
Typical Dosing
FDA Approved Indications
For glaucoma or ocular hypertension: One drop in the affected eye(s) twice daily (morning and evening), as directed by a healthcare provider.
Who Shouldn't Take Cosopt PF?
Cosopt PF should not be used in individuals with:
- Asthma or severe chronic obstructive pulmonary disease (COPD)
- Bradycardia (slow heart rate) or heart block
- Known hypersensitivity to dorzolamide, timolol, or any other ingredients in the formulation
Advice From The Pharmacist
- Wash your hands before using the drops to avoid contamination.
- Tilt your head back and apply one drop into the affected eye. Keep your eye closed for a few minutes after application to allow the medication to be absorbed.
- Avoid touching the tip of the dropper to your eye or any surface to prevent contamination.
- Discard the single-use container after use, even if some solution remains.
- If you are using other eye drops, wait at least 10 minutes between administering different medications.
Side Effects of Cosopt PF
Common Side Effects
- Blurred vision
- Dry eyes
- Burning or stinging sensation in the eyes
- Bitter taste in the mouth
Uncommon/Severe Side Effects
- Difficulty breathing or wheezing
- Swelling of the eyes, face, or throat
- Severe eye irritation or redness
Risks and Warnings of Cosopt PF
Respiratory Risks: Timolol can worsen breathing problems in patients with asthma or COPD. Inform your doctor if you have a history of respiratory conditions.
Cardiovascular Effects: Timolol may cause bradycardia (slow heart rate) or exacerbate heart failure in susceptible individuals.
Allergic Reactions: Discontinue use if you experience signs of an allergic reaction, such as swelling, itching, or rash.
Interactions with Cosopt PF
Common Drug Interactions
Beta-blockers: Using other beta-blocker medications with Cosopt PF may increase the risk of low heart rate or hypotension.
Oral carbonic anhydrase inhibitors: Combining Cosopt PF with oral carbonic anhydrase inhibitors like acetazolamide may increase the risk of metabolic acidosis.
Other eye drops: Use other ophthalmic solutions with caution and allow at least 10 minutes between different medications.
Alternatives to Cosopt PF
- Combigan (brimonidine and timolol): Another combination eye drop for reducing intraocular pressure.
- Trusopt (dorzolamide): A standalone carbonic anhydrase inhibitor used for lowering eye pressure.
- Timoptic (timolol): A beta-blocker eye drop used alone to reduce eye pressure in glaucoma patients.
- Alphagan P (brimonidine): A different class of eye drop for lowering intraocular pressure.
