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Cortifoam
Cortifoam (hydrocortisone acetate) is a topical corticosteroid in a foam form used to treat mild to moderate ulcerative colitis and proctitis (inflammation of the rectum). It works by reducing inflammation, swelling, and irritation in the rectum and lower intestine, providing relief from symptoms such as pain, diarrhea, and bleeding.
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Frequently Asked Questions
How long does it take for Cortifoam to work?
Improvement in symptoms like rectal pain and inflammation may be noticed within a few days to a week, but full effects may take 2 to 3 weeks of consistent use.
Can Cortifoam be used long-term?
Cortifoam is typically prescribed for short-term use, usually 2 to 3 weeks, as long-term use increases the risk of side effects like skin thinning and adrenal suppression.
What should I do if I miss a dose of Cortifoam?
If you miss a dose, use it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can Cortifoam be used for conditions other than ulcerative colitis?
Cortifoam is primarily used for ulcerative proctitis and ulcerative colitis affecting the rectum. It may be used off-label for other inflammatory bowel diseases as directed by your healthcare provider.
Are there any dietary restrictions while using Cortifoam?
There are no specific dietary restrictions while using Cortifoam, but maintaining a healthy, balanced diet can support overall gastrointestinal health.
Comprehensive Drug Guide
How Does Cortifoam Work?
Cortifoam works by delivering hydrocortisone acetate, a corticosteroid, directly to the inflamed area of the rectum and lower colon. Hydrocortisone reduces inflammation by inhibiting the release of inflammatory mediators, thereby decreasing swelling, redness, and irritation in the affected tissues.
Common Dosages
- Rectal foam: Each applicator delivers approximately 90 mg of hydrocortisone acetate.
Typical Dosing
- The usual dose of Cortifoam is one application (90 mg) once or twice daily, administered rectally for 2 to 3 weeks, or as directed by your healthcare provider. The dose may be tapered off as symptoms improve.
Typical Dosing
FDA Approved Indications
- Ulcerative proctitis
- Mild to moderate ulcerative colitis affecting the rectum
Who Shouldn't Take Cortifoam?
- Known hypersensitivity to hydrocortisone or any component of the formulation.
- Rectal or gastrointestinal infections, such as bacterial, fungal, or viral infections (e.g., tuberculosis, herpes simplex).
Advice From The Pharmacist
- Administer Cortifoam rectally using the applicator provided, preferably after a bowel movement for maximum effectiveness.
- Do not use more than the prescribed dose, as prolonged use of corticosteroids may lead to side effects.
- If symptoms do not improve within a few weeks, consult your healthcare provider.
Side Effects of Cortifoam
Common Side Effects
- Rectal irritation or burning
- Increased bowel movements
- Dryness or itching
Uncommon/Severe Side Effects
- Adrenal suppression (especially with prolonged use)
- Skin thinning at the site of application
- Systemic steroid effects, such as weight gain or high blood pressure
Risks and Warnings of Cortifoam
- Adrenal Suppression: Prolonged use of Cortifoam can suppress adrenal function, leading to potential systemic effects, such as fatigue, weight gain, or hormonal imbalances.
- Infection Risk: Corticosteroids can lower the immune system's ability to fight infections. Do not use Cortifoam if you have a rectal infection.
- Skin Atrophy: Long-term use may cause thinning of the skin at the site of application.
Interactions with Cortifoam
Common Drug Interactions
- Other corticosteroids: Using other systemic or topical corticosteroids with Cortifoam can increase the risk of side effects like adrenal suppression or skin thinning.
- Immunosuppressants: Using immunosuppressive drugs alongside Cortifoam can increase the risk of infections.
- Vaccines: Live vaccines should be avoided during corticosteroid therapy, as the immune response may be weakened.
Alternatives to Cortifoam
- Canasa (mesalamine): A rectal suppository used for ulcerative proctitis to reduce inflammation in the rectum.
- Proctofoam: Another rectal foam that contains a combination of hydrocortisone and pramoxine for inflammation and pain relief in proctitis.
- Anucort-HC: A hydrocortisone rectal suppository used to treat similar conditions of rectal inflammation.
