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Canasa

Canasa, also known as mesalamine, is an antiinflammatory drug. It is predominantly used for treating and avoiding flareups in patients with ulcerative colitis (UC), a type of inflammatory bowel disease. While it does have a few side effects like nausea, headache, and bloating, your doctor will weigh these against its ability to help keep your UC in check.

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Frequently Asked Questions

Can I take Canasa if I'm pregnant or breastfeeding?
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While Canasa isn't expected to harm an unborn baby, and it's unclear whether it passes into breast milk, always talk to your healthcare provider if you're pregnant, planning to become pregnant, or are breastfeeding.

Does Canasa cause staining?
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Yes, Canasa can cause discoloration or staining of surfaces it comes into contact with, including fabric, flooring, painted surfaces, marble, granite, vinyl, and enamel.

I missed a dose of Canasa, what should I do?
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Don't worry. If it's close to the time for your next dose, skip the missed one. Otherwise, take it as soon as you can. Just make sure not to double your next dose.

I'm experiencing headaches; could Canasa be the cause?
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Headaches are a known side effect of Canasa. If they're severe or don't go away, talk to your doctor.

Comprehensive Drug Guide

How Does Canasa Work?

Canasa is a bowelspecific aminosalicylate, it works by reducing inflammation in the colon, modifying the local chemical responses involved in the inflammatory process.

What is Canasa Used For?

FDA indications: Canasa is used to treat mild to moderate ulcerative colitis, proctitis, and proctosigmoiditis.

Offlabel uses: While primarily used to treat the above conditions, it has also been used in the management of Crohn's disease.

Common Dosages

Suppository: 1,000 mg

Oral delayedrelease tablet: 500mg, 800mg, 1.2g

Typical Dosing

FDA Approved Indications

  • Mild to moderate ulcerative colitis, proctitis, and proctosigmoiditis: 500mg to 1g in single or divided doses.

Off-Label Uses

  • Management of Crohn's: 500mg to 1g in single or divided doses based on your doctor's advice.

Who Shouldn't Take Canasa?

  • Persons hypersensitive to salicylates like aspirin or mesalamines.
  • People with kidney dysfunction.
  • Individuals with known or suspected urinary tract obstruction.
  • If you have confirmed pyloric stenosis.
  • Those with serious gastric retention issues.

Advice From The Pharmacist

  • It's crucial to take Canasa exactly as your doctor has instructed.
  • Never crush, break, or chew the tablet ? always swallow it whole.
  • You may notice a residue in your stool; this is usually the covering of the pill and is quite normal.
  • If you miss a dose, take it as soon as you remember, unless it?s close to the time of the next scheduled dose.
  • In the event of an overdose, seek immediate medical attention.

Side Effects of Canasa

Common Side Effects

  • You might face issues like bloating, gas, or stomach pain.
  • You might experience some rectal pain or discomfort.
  • You might encounter constipation.
  • Fever and headache could be possible side effects.

Uncommon/Severe Side Effects

  • Uncommon side effects:
  • You might get rashes or irritation on your skin.
  • You could notice changes in your menstrual periods.
  • Sudden hair loss could be a side effect.
  • Rare side effects:
  • You may encounter serious allergic reactions like rash, itching, or swelling of the face/tongue/throat, severe dizziness, or trouble breathing. Immediate medical attention is needed in such scenarios.
  • Chest pain and vision changes, although rare, could take place.
  • Severe side effects:
  • Difficulty in breathing or swallowing, if it happens, is severe and requires immediate medical attention.
  • Severe nausea or stomach cramps are also serious and you should get medical help.
  • If you notice blood or mucus in your stools, it is a severe side effect; get medical help right away.
  • Unexpected bleeding or bruising is also considered severe, you should seek immediate medical attention.
  • Rapid weight gain is another severe side effect that you should discuss with your doctor without delay.

Risks and Warnings of Canasa

  • If you're hypersensitive to mesalamine or have a history of kidney problems, Canasa might not be for you.
  • Canasa can cause an acute intolerance syndrome that may be difficult to distinguish from a flare of ulcerative colitis. Symptoms include cramping, abdominal pain, bloody diarrhea, and occasionally fever, headache, and rash. If these occur, contact your healthcare provider immediately.
  • Prolonged gastric retention can cause complications. If you have pyloric stenosis or urinary tract obstruction, discuss it with your doctor.

Interactions with Canasa

Common Drug Interactions

  • Azathioprine
  • 6mercaptopurine (6MP)
  • Anticoagulants (like warfarin)
  • Probenecid
  • Methotrexate

Alternatives to Canasa

  • Sulfasalazine
  • Balsalazide
  • Olsalazine