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Cortenema
Cortenema (generic name: hydrocortisone enema) is a corticosteroid medication used to treat inflammation of the lower intestines, commonly in conditions like ulcerative colitis and proctitis. It works by reducing inflammation, swelling, and irritation in the bowel, helping to manage symptoms like diarrhea, bleeding, and abdominal pain.
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Frequently Asked Questions
How long does it take for Cortenema to work?
Most patients experience symptom relief within a few days of starting treatment, but full effects may take up to a few weeks.
Can Cortenema cause weight gain?
While weight gain is less common with rectal corticosteroids, long-term use may lead to some systemic absorption, which could contribute to weight gain.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double up.
Can Cortenema be used long-term?
Cortenema is usually prescribed for short-term use, but in some cases, long-term use may be necessary. Discuss with your doctor the risks and benefits of extended use.
Are there dietary restrictions while using Cortenema?
There are no specific dietary restrictions, but maintaining a balanced diet and staying hydrated can support your overall health during treatment.
Comprehensive Drug Guide
How Does Cortenema Work?
Cortenema works by delivering hydrocortisone, a potent anti-inflammatory steroid, directly to the lower intestine. Hydrocortisone reduces the release of inflammatory substances in the body, helping to soothe the intestinal lining, decrease swelling, and relieve symptoms of bowel inflammation.
Common Dosages
- Cortenema is available in a 100 mg/60 mL rectal enema formulation, administered once daily, usually at bedtime.
Typical Dosing
- For ulcerative colitis or proctitis: The typical dose is one 100 mg enema, administered rectally at bedtime. Treatment duration is usually 21 days but may vary based on the response.
Typical Dosing
FDA Approved Indications
- Ulcerative colitis
- Proctitis
- Other inflammatory bowel diseases (IBD) affecting the lower intestines
Who Shouldn't Take Cortenema?
- Systemic fungal infections
- Known hypersensitivity to hydrocortisone or any ingredients in the enema
Advice From The Pharmacist
- Ensure the enema is administered correctly by lying on your left side with your knees bent during insertion.
- Try to retain the enema for at least 30 minutes or longer, preferably overnight, to allow the medication to work.
- Store the enema bottles at room temperature, away from light.
Side Effects of Cortenema
Common Side Effects
- Rectal irritation
- Bloating
- Nausea
- Headache
Uncommon/Severe Side Effects
- Systemic absorption leading to corticosteroid-related side effects such as weight gain, increased blood sugar, or fluid retention
Risks and Warnings of Cortenema
- Systemic Effects: Long-term use of corticosteroids, even rectally, may lead to systemic absorption and associated side effects like weight gain, osteoporosis, or increased blood pressure.
- Infection Risk: Steroid use can weaken the immune system, increasing the risk of infections. Report any signs of infections to your healthcare provider.
Interactions with Cortenema
Common Drug Interactions
- NSAIDs: Use of NSAIDs like ibuprofen with corticosteroids may increase the risk of gastrointestinal bleeding.
- Immunosuppressants: Combining Cortenema with other immunosuppressive drugs may further increase the risk of infections.
Alternatives to Cortenema
- Canasa (mesalamine suppository): Used for ulcerative proctitis.
- Rowasa (mesalamine enema): Another enema-based treatment for ulcerative colitis.
- Prednisone: An oral corticosteroid often used for more widespread inflammation.
