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Consensi
Consensi is a combination of amlodipine (a calcium channel blocker) and celecoxib (a nonsteroidal anti-inflammatory drug, or NSAID). It is used to treat high blood pressure (hypertension) and the management of osteoarthritis pain in adults who need both medications. Amlodipine helps lower blood pressure by relaxing blood vessels, while celecoxib reduces pain and inflammation in conditions such as osteoarthritis.
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Frequently Asked Questions
Can I take Consensi for both blood pressure and pain management?
Yes, Consensi is specifically designed to treat hypertension and osteoarthritis pain in one pill.
Can I take Consensi if I have heart disease?
Celecoxib, part of Consensi, can increase the risk of heart attack or stroke. Discuss your condition with your healthcare provider before starting this medication.
What should I do if I miss a dose?
Take the missed dose as soon as you remember, but if it’s almost time for the next dose, skip the missed dose. Do not double up doses.
Can I take other NSAIDs while using Consensi?
No, using additional NSAIDs may increase your risk of serious gastrointestinal or cardiovascular side effects.
Does Consensi cause weight gain?
Weight gain can occur due to edema caused by amlodipine, but this is not a common side effect. Consult your doctor if you experience swelling or rapid weight gain.
Comprehensive Drug Guide
How Does Consensi Work?
- Amlodipine works by blocking calcium channels in the smooth muscle of blood vessels, leading to relaxation and dilation of the arteries, which helps lower blood pressure.
- Celecoxib inhibits COX-2 enzymes, which are responsible for producing prostaglandins that cause pain and inflammation. This reduces the symptoms of osteoarthritis.
Common Dosages
- Tablets containing amlodipine 2.5 mg, 5 mg, or 10 mg, each paired with 200 mg of celecoxib.
Typical Dosing
- The typical dose for Consensi is one tablet once daily, with the strength adjusted based on the patient’s blood pressure and pain management needs.
Typical Dosing
FDA Approved Indications
- Treatment of hypertension in adults.
- Management of osteoarthritis pain in patients who require both treatments.
Who Shouldn't Take Consensi?
- Hypersensitivity to amlodipine, celecoxib, or other NSAIDs.
- Severe liver or kidney impairment.
- History of allergic reactions to sulfonamides or NSAIDs.
- Coronary artery bypass graft (CABG) surgery due to increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Consensi once daily, with or without food.
- Regular monitoring of blood pressure and kidney function is required while on this medication.
- Avoid using other NSAIDs or high-dose aspirin while on Consensi, as it increases the risk of gastrointestinal and cardiovascular side effects.
Side Effects of Consensi
Common Side Effects
- Dizziness
- Edema (swelling)
- Heartburn
- Nausea
Uncommon/Severe Side Effects
- Heart attack or stroke due to celecoxib’s cardiovascular risk.
- Gastrointestinal bleeding or ulceration.
- Kidney impairment or liver dysfunction.
Risks and Warnings of Consensi
- Cardiovascular risk: Celecoxib can increase the risk of heart attack or stroke, particularly in patients with cardiovascular disease.
- Gastrointestinal risk: NSAIDs like celecoxib can cause bleeding, ulceration, or perforation of the stomach or intestines, which can be fatal.
- Fluid retention: Amlodipine may cause swelling in the extremities (edema), especially in higher doses.
Interactions with Consensi
Common Drug Interactions
- Aspirin: Taking high-dose aspirin with Consensi can increase the risk of gastrointestinal bleeding.
- Blood pressure medications: Other antihypertensives may enhance the blood pressure-lowering effects of amlodipine.
- Anticoagulants: Taking celecoxib with blood thinners (e.g., warfarin) can increase the risk of bleeding.
Alternatives to Consensi
- Norvasc (amlodipine): A single-agent calcium channel blocker for treating hypertension.
- Celebrex (celecoxib): A single-agent NSAID for managing osteoarthritis pain.
- Lisinopril and NSAID combinations: Separate drugs for managing hypertension and pain.
