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Clindesse
Clindesse (clindamycin phosphate) is a vaginal antibiotic cream used to treat bacterial vaginosis (BV) in women. It works by reducing the overgrowth of certain bacteria that cause BV, restoring the natural balance of vaginal flora. Clindesse is often preferred because it is administered as a single-dose treatment, making it convenient for patients.
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Frequently Asked Questions
How soon does Clindesse start working?
Symptoms of bacterial vaginosis typically start to improve within a few days after using Clindesse.
Can I use Clindesse while pregnant?
Clindesse may be used during pregnancy if prescribed by a doctor, but consult your healthcare provider to ensure it’s the right treatment for you.
Can I use Clindesse if I’m on my period?
It’s recommended to avoid using Clindesse during menstruation, as it may not be as effective. Wait until your period ends to start treatment.
Does Clindesse cure bacterial vaginosis with one dose?
Yes, Clindesse is designed to be a single-dose treatment, and in most cases, one dose is enough to treat BV.
Can I have sex while using Clindesse?
It is advised to avoid sexual intercourse while using Clindesse, as the cream can reduce its effectiveness and increase the risk of spreading the infection to your partner.
Comprehensive Drug Guide
How Does Clindesse Work?
Clindesse works by inhibiting bacterial protein synthesis, which stops the growth of bacteria that cause bacterial vaginosis. By reducing the bacterial population in the vagina, it helps restore the normal balance of vaginal flora.
Common Dosages
- Single-dose vaginal cream, with each dose containing 100 mg clindamycin phosphate (equivalent to 5 g of cream).
Typical Dosing
- Single dose: Insert the entire contents of one prefilled applicator into the vagina at bedtime.
Typical Dosing
FDA Approved Indications
- Treatment of bacterial vaginosis (BV) in women.
Who Shouldn't Take Clindesse?
- Hypersensitivity to clindamycin or lincomycin.
- History of antibiotic-associated colitis.
Advice From The Pharmacist
- Insert Clindesse at bedtime to ensure the medication stays in place.
- Avoid sexual intercourse or using tampons during treatment.
- Use the full dose, even if symptoms improve after one use, to ensure full treatment.
Side Effects of Clindesse
Common Side Effects
- Vaginal itching
- Discharge
- Burning sensation
Uncommon/Severe Side Effects
- Severe diarrhea due to Clostridium difficile-associated colitis, a rare but serious condition caused by bacterial overgrowth in the intestines.
Risks and Warnings of Clindesse
- Colitis risk: Like other forms of clindamycin, Clindesse carries a risk of pseudomembranous colitis. Discontinue use and contact your doctor if you develop severe diarrhea.
- Pregnancy: Clindesse may be used during pregnancy if the benefits outweigh the risks, but consult your doctor for advice.
Interactions with Clindesse
Common Drug Interactions
- Other vaginal treatments: Avoid using other vaginal products or medications (e.g., tampons, douches) while using Clindesse.
- Oral antibiotics: Using oral antibiotics alongside Clindesse can increase the risk of antibiotic resistance.
Alternatives to Clindesse
- Metronidazole (Flagyl): Another antibiotic commonly used to treat bacterial vaginosis.
- Tinidazole: An alternative to metronidazole for the treatment of BV.
- Boric acid suppositories: Sometimes used as an adjunct treatment for chronic BV.
