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Cimduo
Cimduo is a combination medication containing lamivudine and tenofovir disoproxil fumarate (TDF), both of which are antiretroviral drugs used to treat HIV-1 infection in adults and pediatric patients weighing at least 35 kg. Both components are nucleoside reverse transcriptase inhibitors (NRTIs) that block the replication of HIV, helping to lower the viral load and improve immune function.
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Frequently Asked Questions
Can I take Cimduo with food?
Yes, Cimduo can be taken with or without food.
How often do I need to take Cimduo?
Cimduo is taken once daily.
Can Cimduo cure HIV?
No, Cimduo is not a cure for HIV. It helps control the infection, allowing individuals to live healthier lives, but HIV can still be transmitted to others.
Do I need to monitor my kidney function while on Cimduo?
Yes, regular monitoring of kidney function is essential, as tenofovir can affect the kidneys.
What should I do if I miss a dose of Cimduo?
If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue your regular schedule.
Comprehensive Drug Guide
How Does Cimduo Work?
Cimduo works by inhibiting reverse transcriptase, an enzyme that HIV needs to replicate. By blocking this enzyme, Cimduo helps to reduce the amount of HIV in the blood, allowing the immune system to function more effectively and decreasing the risk of developing AIDS or other infections.
Common Dosages
- Tablets: Each tablet contains 300 mg of tenofovir disoproxil fumarate and 300 mg of lamivudine.
Typical Dosing
- The typical dose is one tablet once daily taken with or without food. The dose may need adjustment in patients with renal impairment.
Typical Dosing
FDA Approved Indications
- Treatment of HIV-1 infection in combination with other antiretroviral agents.
Who Shouldn't Take Cimduo?
- Severe renal impairment
- Known hypersensitivity to lamivudine or tenofovir disoproxil fumarate.
Advice From The Pharmacist
- Take Cimduo once daily as prescribed. Do not miss doses, as this can lead to viral resistance.
- Regularly monitor kidney function, as tenofovir can affect the kidneys.
- Stay hydrated to reduce the risk of kidney-related side effects.
Side Effects of Cimduo
Common Side Effects
- Nausea
- Headache
- Fatigue
- Diarrhea
Uncommon/Severe Side Effects
- Lactic acidosis
- Severe liver enlargement (hepatomegaly)
- Kidney problems
Risks and Warnings of Cimduo
- Lactic acidosis: NRTIs, including those in Cimduo, have been associated with the risk of lactic acidosis, which is a potentially life-threatening condition.
- Renal impairment: Cimduo can worsen kidney function, so regular kidney function tests are essential.
- Bone density: Long-term use of tenofovir may reduce bone density, leading to a higher risk of fractures.
Interactions with Cimduo
Common Drug Interactions
- Antivirals: Avoid co-administration with other drugs that contain tenofovir or lamivudine to avoid overdose.
- NSAIDs: Non-steroidal anti-inflammatory drugs (e.g., ibuprofen) can increase the risk of kidney problems when taken with Cimduo.
Alternatives to Cimduo
- Descovy (emtricitabine/tenofovir alafenamide): Another NRTI combination for treating HIV.
- Truvada (emtricitabine/tenofovir disoproxil fumarate): Another NRTI combination that is commonly used in combination therapy for HIV.
