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Cervidil
Cervidil (dinoprostone) is a prostaglandin E2 analog used to assist in cervical ripening in pregnant women who are at or near term and require labor induction. It helps soften and dilate the cervix, making it easier for labor to progress. Cervidil is typically used in a hospital setting under the supervision of healthcare professionals.
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Frequently Asked Questions
How long does it take for Cervidil to work?
Cervidil typically starts to work within a few hours after insertion, helping to soften the cervix. Labor induction may follow after the insert is removed.
Can Cervidil cause labor to progress too quickly?
Yes, Cervidil can cause uterine hyperstimulation, leading to overly strong or frequent contractions. If this occurs, the insert will be removed to help slow down contractions.
Is Cervidil painful to use?
The insertion itself is typically not painful, but you may experience discomfort or contractions as the cervix begins to ripen and labor progresses.
Can Cervidil be used in all pregnancies?
Cervidil is not recommended for all pregnancies, particularly in women with conditions such as placenta previa, fetal distress, or ruptured membranes.
What happens if Cervidil doesn’t work?
If Cervidil does not successfully induce labor, your healthcare provider may consider other methods, such as oxytocin (Pitocin) or a cesarean delivery.
Comprehensive Drug Guide
How Does Cervidil Work?
Cervidil works by mimicking the effects of natural prostaglandin E2, which helps to soften and dilate the cervix (cervical ripening). This action prepares the cervix for labor induction, helping to facilitate the onset of contractions and labor.
Common Dosages
- Vaginal insert: 10 mg dinoprostone
Typical Dosing
- For cervical ripening: One vaginal insert containing 10 mg dinoprostone is placed near the cervix. It releases medication over 12 hours. The insert is removed once labor progresses or if uterine hyperstimulation occurs.
Typical Dosing
FDA Approved Indications
- Cervical ripening in pregnant women who are at or near term and require labor induction.
Who Shouldn't Take Cervidil?
- Known hypersensitivity to dinoprostone or other prostaglandins.
- Active labor or ruptured membranes.
- Conditions where vaginal delivery is not recommended (e.g., placenta previa, fetal distress).
Advice From The Pharmacist
- Cervidil is administered by healthcare providers in a hospital setting. You will be monitored for contractions and cervical changes after the insertion.
- If labor progresses rapidly or if uterine hyperstimulation occurs, the insert will be removed.
- Inform your healthcare provider if you experience intense contractions or abnormal pain during use.
Side Effects of Cervidil
Common Side Effects
- Uterine contractions
- Nausea
- Vomiting
- Fever
- Back pain
Uncommon/Severe Side Effects
- Uterine hyperstimulation (excessive contractions)
- Fetal distress
- Allergic reactions (swelling, difficulty breathing)
Risks and Warnings of Cervidil
- Uterine Hyperstimulation: Cervidil can cause excessive uterine contractions, which may lead to complications such as fetal distress or uterine rupture. Close monitoring is required.
- Caution in Women with Asthma: Prostaglandins may exacerbate asthma symptoms. Cervidil should be used with caution in women with a history of asthma.
Interactions with Cervidil
Common Drug Interactions
- Oxytocin (Pitocin): Cervidil should not be used concurrently with oxytocin or other labor-inducing agents, as this increases the risk of uterine hyperstimulation.
- Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Concurrent use of NSAIDs may reduce the effectiveness of prostaglandins like Cervidil.
Alternatives to Cervidil
- Cytotec (misoprostol): Another prostaglandin used for cervical ripening and labor induction.
- Prepidil (dinoprostone): A gel form of dinoprostone used for cervical ripening.
- Oxytocin (Pitocin): A medication used to induce labor or strengthen uterine contractions once labor has started.
