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Carac
Carac (fluorouracil) is a topical chemotherapy medication used to treat actinic keratosis, a precancerous skin condition caused by sun exposure. It is also used for certain types of basal cell carcinoma. Carac works by inhibiting the growth of abnormal cells on the skin, helping to prevent the progression to skin cancer.
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Frequently Asked Questions
How long does it take for Carac to work?
Carac usually takes 2 to 4 weeks to start showing visible results in the treatment of actinic keratosis. Healing may continue for several weeks after stopping the treatment.
Can I use Carac on healthy skin?
No, Carac should only be applied to the affected areas, as it can cause irritation and damage to healthy skin.
Is Carac safe during pregnancy?
No, Carac should not be used during pregnancy, as it can cause harm to the fetus.
Can I use makeup or moisturizers while using Carac?
It is best to avoid using cosmetics or other topical products on the treated areas, as they can interfere with the effectiveness of Carac and may worsen skin irritation.
What should I do if I miss a dose of Carac?
If you miss a dose, apply it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Comprehensive Drug Guide
How Does Carac Work?
Carac works by interfering with the DNA synthesis of abnormal skin cells. Fluorouracil inhibits the enzyme thymidylate synthase, preventing the formation of thymidine, which is essential for DNA replication. This leads to the death of rapidly dividing precancerous or cancerous cells.
Common Dosages
- Topical cream: 0.5% fluorouracil
Typical Dosing
- For actinic keratosis: Apply Carac once daily to the affected area for 2 to 4 weeks, as directed by your healthcare provider.
- For superficial basal cell carcinoma: Apply as prescribed by your healthcare provider, typically for several weeks.
Typical Dosing
FDA Approved Indications
- Actinic keratosis
- Superficial basal cell carcinoma (in certain cases)
Who Shouldn't Take Carac?
- Known hypersensitivity to fluorouracil or any component of the formulation.
- Pregnancy or breastfeeding, as it can harm the fetus or infant.
- Dihydropyrimidine dehydrogenase (DPD) deficiency, as this can lead to severe toxicity.
Advice From The Pharmacist
- Apply Carac only to the affected areas as prescribed. Avoid contact with healthy skin, eyes, mouth, or mucous membranes.
- Use sunscreen and protective clothing when outdoors, as Carac increases skin sensitivity to sunlight.
- Carac may cause redness, irritation, and peeling in the treatment area, which is a sign that the medication is working. Contact your healthcare provider if the irritation becomes severe or unmanageable.
Side Effects of Carac
Common Side Effects
- Skin redness
- Peeling
- Burning or stinging sensation
- Itching
Uncommon/Severe Side Effects
- Severe skin reactions
- Allergic reactions (rash, swelling, difficulty breathing)
- Systemic toxicity (in cases of overdose or improper use)
Risks and Warnings of Carac
- Photosensitivity: Carac increases the skin’s sensitivity to sunlight, leading to a higher risk of sunburn. Use sunscreen and protective clothing.
- Severe Skin Reactions: Carac can cause severe skin irritation, including blistering and ulceration, in some cases. Discontinue use and contact your healthcare provider if this occurs.
- Pregnancy Risk: Carac is contraindicated in pregnancy, as it may cause fetal harm.
Interactions with Carac
Common Drug Interactions
- Other Topical Medications: Using other topical products, particularly those that contain alcohol or irritating ingredients, can increase skin irritation when used with Carac.
- Systemic Chemotherapy: Caution should be exercised when Carac is used alongside other chemotherapy agents, as it can increase the risk of side effects.
Alternatives to Carac
- Efudex (fluorouracil): Another topical fluorouracil cream used to treat actinic keratosis and superficial basal cell carcinoma.
- Aldara (imiquimod): A topical immune response modifier used to treat actinic keratosis and superficial basal cell carcinoma.
- Picato (ingenol mebutate): A topical gel used to treat actinic keratosis.
