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Calcitrene
Calcitrene, also known as calcipotriene, is a synthetic derivative of vitamin D. It's typically used as a topical treatment to control the speed of skin cell growth, which can be helpful in conditions like psoriasis. Common side effects may include skin irritation or sensitivity, but your healthcare provider will always weigh the treatment benefits against possible side effects.
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Frequently Asked Questions
Can I apply Calcitrene to the face?
It's generally advised to avoid applying Calcitrene on the face as the facial skin is more sensitive and may react adversely to the medication.
Does Calcitrene make you more sensitive to the sun?
Calcitrene can make your skin more sensitive to the sun, so it's best to limit your sun exposure and use sunprotective measures like sunscreen or protective clothing.
I accidentally got some Calcitrene in my eyes, what should I do?
If Calcitrene gets into your eyes, immediately rinse with plenty of water and seek medical advice.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it is near the time of your next dose, skip it and resume your regular dosing schedule. Do not double the dose to catch up.
Comprehensive Drug Guide
How Does Calcitrene Work?
Calcitrene, or calcipotriene, is a synthetic vitamin D3 analog that regulates skin cell proliferation and differentiation. It effectively treats plaquetype psoriasis by controlling the abnormal rapidity of epidermal cell production.
What is Calcitrene Used For?
FDA indications: Calcitrene is primarily indicated for the treatment of mild to moderate plaque psoriasis.
Offlabel uses: It may be used offlabel for other forms of psoriasis or skin disorders as decided by a healthcare professional.
Common Dosages
Cream, Ointment, and Scalp Solution: 0.005%
Typical Dosing
FDA Approved Indications
- Plaque psoriasis: Apply to affected areas once or twice daily, not exceeding 100g per week.
Off-Label Uses
- The dosing may vary based on the severity of the condition and the discretion of the healthcare provider.
Who Shouldn't Take Calcitrene?
- Have a known hypersensitivity or allergy to calcipotriene or any of the ingredients in Calcitrene.
- Have high calcium levels in the body (hypercalcemia) or a history thereof.
- Have certain types of skin infections or skin conditions.
- Are under 18 years old unless specifically instructed by a healthcare provider (the safety and effectiveness of Calcitrene in pediatric patients are not established).
- Are pregnant, planning to become pregnant, or are breastfeeding (it's not known whether Calcitrene harms the baby but should be used only if needed).
Advice From The Pharmacist
- Apply Calcitrene only to affected areas, avoiding normal skin.
- Avoid excessive sun and artificial UV light exposure while using Calcitrene.
- Calcitrene is for external use only. Avoid contact with the face, mouth, and eyes.
- Do not use occlusive dressings unless directed by your healthcare provider.
- Inform your healthcare provider if your symptoms do not improve after 2 weeks of treatment.
- Do not use Calcitrene in skin folds or under diapers or plastic pants if it's for a child.
- If you experience excessive skin irritation, discontinue use and consult your healthcare provider.
Side Effects of Calcitrene
Common Side Effects
- Skin irritation or burning at the application site.
- Redness or rashes.
- Itchy skin
Uncommon/Severe Side Effects
- Uncommon side effects:
- Hives
- Trouble breathing
- Rare side effects:
- Swelling of lips, face, tongue, or throat.
- Changes in the color of treated skin.
- Severe side effects:
- If you experience severe skin irritation, worsening of your skin condition, or signs of high calcium levels (nausea, fatigue, mood changes, headache, etc.), seek immediate medical attention.
Risks and Warnings of Calcitrene
- While Calcitrene can be an effective treatment for plaque psoriasis, people with hypersensitivity to calcipotriene or any of the formulation components should avoid its use.
- If you have a history of hypercalcemia or other metabolic disorders, discuss this with your healthcare provider before starting usage.
- Before starting treatment, patients with severe liver or kidney disease should consult their healthcare provider.
- During pregnancy and breastfeeding, caution should be exercised due to the limited data on Calcitrene use in these conditions.
- Pediatric usage should only be considered under strict medical supervision as the safety and efficacy of Calcitrene in this age group are not established.
Interactions with Calcitrene
Common Drug Interactions
- Drugs that increase systemic absorption of calcipotriene.
- Other topical products, unless advised by your healthcare provider.
Alternatives to Calcitrene
- Betamethasone
- Hydrocortisone
- Clobetasol
- Tazarotene
- Fluocinonide
- Triamcinolone
- Ustekinumab
