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Bryhali
Bryhali (halobetasol propionate) is a topical corticosteroid used to treat plaque psoriasis in adults. It helps reduce inflammation, redness, itching, and scaling associated with psoriasis. Bryhali is specifically formulated as a lotion to be applied directly to the affected areas of the skin. This medication is considered a high-potency corticosteroid and is typically used for short-term treatment to avoid side effects associated with long-term steroid use.
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Frequently Asked Questions
How long does it take for Bryhali to work?
Most patients begin to see an improvement in their psoriasis symptoms within 2 to 4 weeks of starting treatment, but the full effect may take longer.
Can I use Bryhali on my face?
No, Bryhali is typically not recommended for use on the face due to the higher risk of side effects like skin thinning in this sensitive area. Always follow your healthcare provider’s instructions regarding where to apply the medication.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up doses.
Is Bryhali safe for long-term use?
No, Bryhali is generally prescribed for short-term use (up to 8 weeks). Long-term use of high-potency corticosteroids can lead to serious side effects, including skin thinning and adrenal suppression.
Can Bryhali cause weight gain or other systemic effects?
While rare, systemic absorption of high-potency steroids like Bryhali can cause side effects such as weight gain, fluid retention, or hormonal imbalances if used for prolonged periods or over large areas of the body.
Comprehensive Drug Guide
How Does Bryhali Work?
- Reducing inflammation in the skin by suppressing the release of inflammatory chemicals (e.g., cytokines) that contribute to the symptoms of plaque psoriasis.
- It also inhibits immune responses that cause excessive skin cell turnover, helping to reduce the thickened patches of skin seen in plaque psoriasis.
Common Dosages
- Topical lotion: 0.01% halobetasol propionate
Typical Dosing
- The typical dosing for Bryhali is to apply a thin layer to the affected skin areas once daily for up to 8 weeks. Treatment beyond 8 weeks is not recommended unless directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Treatment of plaque psoriasis in adults
Who Shouldn't Take Bryhali?
- Known hypersensitivity to halobetasol propionate or any other components of the lotion.
- Skin infections in the treatment area, as corticosteroids can exacerbate infections.
Advice From The Pharmacist
- Apply Bryhali only to the affected areas of the skin, and avoid contact with the face, eyes, mouth, and groin unless directed by your healthcare provider.
- Do not cover treated areas with bandages or dressings unless instructed by your healthcare provider, as this may increase the absorption of the steroid and risk side effects.
- Use Bryhali only for the duration prescribed, as prolonged use of high-potency steroids can lead to skin thinning and other side effects.
- Wash your hands after applying the lotion unless your hands are being treated.
Side Effects of Bryhali
Common Side Effects
- Skin irritation
- Burning or stinging sensation
- Dry skin
- Itching
Uncommon/Severe Side Effects
- Skin thinning (atrophy)
- Stretch marks (striae)
- HPA axis suppression (a condition in which the body’s natural steroid production is affected)
Risks and Warnings of Bryhali
- Skin atrophy: Long-term use of Bryhali can cause skin thinning or atrophy, especially when used on sensitive areas or under occlusive dressings.
- Hypothalamic-pituitary-adrenal (HPA) axis suppression: Prolonged use of high-potency corticosteroids like Bryhali can suppress the body’s production of natural steroids, leading to potential hormonal imbalances.
- Use in children: Safety and efficacy in pediatric patients have not been established, and children may be more susceptible to systemic side effects due to their larger skin surface area relative to body weight.
Interactions with Bryhali
Common Drug Interactions
- Other topical medications: Using multiple topical products may increase the risk of irritation. Apply different topical products at different times, as directed by your healthcare provider.
- Occlusive dressings: Covering the treated area with occlusive bandages or dressings may increase the absorption of Bryhali and heighten the risk of side effects.
Alternatives to Bryhali
- Clobex (clobetasol propionate): A high-potency topical corticosteroid used for the treatment of moderate to severe plaque psoriasis.
- Taclonex (calcipotriene/betamethasone dipropionate): A combination topical medication used to treat plaque psoriasis.
- Tazorac (tazarotene): A topical retinoid often used in combination with corticosteroids for plaque psoriasis.
