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Biltricide
Biltricide (praziquantel) is an antiparasitic medication used to treat infections caused by schistosoma (schistosomiasis) and liver flukes. It works by paralyzing and killing certain parasites that infect the body. Biltricide is often prescribed for parasitic infections of the liver, intestines, and blood, and is used in both adult and pediatric patients.
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Frequently Asked Questions
How long does it take for Biltricide to work?
Most patients begin to see improvement within a few days after taking Biltricide, but the full effects may take several weeks as the body clears the dead parasites.
Can I drink alcohol while taking Biltricide?
It is best to avoid alcohol while taking Biltricide, as alcohol can increase the risk of liver side effects and may interact with the medication.
Can Biltricide be used for children?
Yes, Biltricide can be used for children over the age of 4, but the dosage must be carefully adjusted based on their body weight.
What should I do if I miss a dose of Biltricide?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Is Biltricide safe for long-term use?
Biltricide is typically prescribed as a short-term treatment for parasitic infections, and long-term use is generally not necessary. If needed for prolonged treatment, close monitoring by a healthcare provider is required.
Comprehensive Drug Guide
How Does Biltricide Work?
Biltricide works by increasing the permeability of the parasite’s cell membrane to calcium, leading to paralysis and eventual death of the parasite. This allows the body’s immune system to clear the dead parasites. The drug is rapidly absorbed, and its effects begin soon after ingestion, helping to clear parasitic infections from the body.
Common Dosages
- Oral tablets: 600 mg praziquantel
Typical Dosing
- For schistosomiasis: The usual dose is 20 mg/kg taken 3 times in a single day at intervals of 4 to 6 hours.
- For liver flukes: The typical dose is 25 mg/kg taken 3 times in a single day at intervals of 4 to 6 hours. Dosing may vary based on the specific parasite being treated.
Typical Dosing
FDA Approved Indications
- Schistosomiasis (infection caused by schistosoma parasites)
- Liver flukes (specifically Clonorchis sinensis and Opisthorchis viverrini)
Who Shouldn't Take Biltricide?
- Known hypersensitivity to praziquantel or any component of the formulation.
- Patients with ocular cysticercosis (tapeworm infection of the eye), as treatment may lead to damage of the eye.
- Severe liver impairment (caution should be exercised).
Advice From The Pharmacist
- Biltricide should be taken with food to improve absorption and reduce the likelihood of gastrointestinal upset.
- Swallow the tablets whole or, if necessary, break them along the scored line. Do not crush or chew the tablets, as they have a bitter taste.
- Avoid driving or operating heavy machinery while taking Biltricide, as the medication may cause dizziness or drowsiness.
- Regular follow-up with your healthcare provider is important to ensure the infection is fully cleared and to monitor for any side effects.
Side Effects of Biltricide
Common Side Effects
- Dizziness
- Headache
- Nausea
- Abdominal pain
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions, such as rash, hives, or difficulty breathing
- Increased liver enzymes or signs of liver dysfunction (jaundice, dark urine)
Risks and Warnings of Biltricide
- Drowsiness and Dizziness: Biltricide can cause drowsiness or dizziness, especially when taken in higher doses. Avoid driving or performing hazardous activities while on the medication.
- Liver Impairment: Biltricide is metabolized by the liver, so patients with significant liver dysfunction should be closely monitored during treatment.
- Ocular Cysticercosis: Biltricide is contraindicated in patients with tapeworm infections of the eye, as it may cause irreversible damage.
Interactions with Biltricide
Common Drug Interactions
- Antiepileptic Drugs: Drugs like carbamazepine and phenytoin may decrease the levels of Biltricide in the body, reducing its effectiveness.
- Cimetidine: This drug may increase the blood levels of Biltricide, potentially increasing the risk of side effects.
- Chloroquine: Used for malaria, this medication may decrease the effectiveness of Biltricide when taken concurrently.
Alternatives to Biltricide
- Alinia (nitazoxanide): Another antiparasitic drug used to treat different parasitic infections, including cryptosporidiosis and giardiasis.
- Mebendazole: Used to treat a range of parasitic infections, including hookworm and roundworm infections.
- Ivermectin: An antiparasitic agent used for a variety of infections, including those caused by roundworms and scabies.
- Albendazole: Another antiparasitic medication used for a wide range of parasitic infections, including tapeworms.
