Azelastine-Fluticasone

Azelastine-Fluticasone is FDA-approved for the treatment of symptoms associated with seasonal and perennial allergic rhinitis in adults and children 6 years of age and older. It is designed to address multiple symptoms of allergic rhinitis, providing more comprehensive relief than single-ingredient treatments.

Azelastine-Fluticasone is contraindicated in patients with a known hypersensitivity to either azelastine hydrochloride, fluticasone propionate, or any other components of the formulation. It should be used with caution in patients with a history of nasal surgery, trauma, or ulcers, as corticosteroids can slow wound healing. Additionally, patients with a history of infections such as tuberculosis, untreated fungal, bacterial, or viral infections should consult their healthcare provider before using this medication.

Patients using Azelastine-Fluticasone should be advised to prime the nasal spray before the first use or if it hasn’t been used for more than a few days. To prime the spray, they should release a few sprays into the air until a fine mist is visible. It’s important to use the medication regularly, even if symptoms improve, to maintain relief. Patients should be cautioned against using this nasal spray for longer than recommended without consulting their healthcare provider, as long-term use of corticosteroids can have systemic effects. Additionally, patients should avoid contact with the eyes, and if the spray does come into contact with the eyes, they should rinse thoroughly with water.

Common side effects of Azelastine-Fluticasone include headache, nosebleeds, sore throat, nasal discomfort, and a bitter taste in the mouth. Some patients may also experience drowsiness or fatigue, which is more commonly associated with the antihistamine component (azelastine).

Serious side effects, though rare, can include vision changes, severe nosebleeds, signs of infection (such as fever, persistent sore throat), and adrenal suppression, especially with long-term use. Patients should seek medical attention if they experience any severe or persistent side effects.

Azelastine-Fluticasone should be used with caution in patients with a history of glaucoma or cataracts, as long-term use of corticosteroids can increase intraocular pressure and contribute to the development of these conditions. The medication may also suppress the immune system, increasing the risk of infections. Patients using the nasal spray for extended periods should be monitored for potential systemic corticosteroid effects, such as adrenal suppression. Additionally, patients should be aware that while the nasal spray provides symptomatic relief, it does not cure allergic rhinitis.

Azelastine-Fluticasone may interact with other medications, including other corticosteroids, anticholinergics, and certain antifungal or antiviral drugs (such as ketoconazole or ritonavir). These interactions can increase the risk of side effects or affect how the medication works. Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions. Alcohol and other central nervous system depressants may increase the sedative effect of azelastine, so patients should be cautious about consuming alcohol while using this medication.

Alternative treatments for allergic rhinitis include other nasal sprays, such as fluticasone alone (Flonase) or azelastine alone (Astelin), as well as oral antihistamines like loratadine (Claritin) or cetirizine (Zyrtec). For severe cases, immunotherapy (allergy shots) may be considered. The choice of treatment depends on the severity of symptoms, patient preference, and response to previous treatments.