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Ativan
Lorazepam is a medication categorized as a benzodiazepine. It's like a calming agent for your brain, primarily used to treat conditions related to anxiety, seizure disorders, or to provide sedation before surgery.
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Frequently Asked Questions
Can I take Lorazepam if I'm pregnant?
It's generally not recommended, as it can harm the unborn baby. Consult with your healthcare provider for advice about this.
Can Lorazepam make me feel drowsy?
Yes, indeed. It's wise to avoid driving or operating machinery after taking this medication until you know how it affects you.
What if I forget a dose of Lorazepam?
If the next dose is near, skip the missed one. Otherwise, take it as soon as you remember. Avoid double dosing.
Can I stop using Lorazepam suddenly?
No, this is not advisable as it can cause withdrawal symptoms. Your doctor will guide you on how to gradually decrease your dose.
Does Lorazepam interact with other medicines?
Yes, it can interact with several other medications including opioids, barbiturates, and antidepressants. Always inform your healthcare provider about all the medications or nutritional supplements you are taking.
Comprehensive Drug Guide
How Does Ativan Work?
Lorazepam is a benzodiazepine that works by enhancing the effects of a certain natural chemical in the body (GABA). It functions by depressing the central nervous system, causing sedation and relief from anxiety.
What is Ativan Used For?
Lorazepam is used for treating anxiety disorders, to cause sedation before medical procedures, and to manage epilepsy. It's also used off-label for agitation from psychotic disorder and withdrawal symptoms from alcohol dependence.
Common Dosages
Lorazepam is commonly manufactured in the following formulations:
Tablets: 0.5 mg, 1 mg, 2 mg
Solution: 2 mg/mL
Injection: 2 mg/mL, 4 mg/mL
Typical Dosing
FDA Approved Indications
- Anxiety: 1 to 10 mg taken 2 to 3 times daily.
- Procedural sedation: 2 to 4 mg administered 2 hours before the procedure.
- Seizures: 4 mg IV given slowly at 2mg/min, may repeat in 10 to 15 minutes.
Off-Label Uses
- Agitation: 2mg IM alone or with haloperidol for 1 to 6 injections in a 12 hour period.
- Alcohol withdrawal: Dose based on symptom severity, typically started at 2 to 4 mg.
Who Shouldn't Take Ativan?
- Have a history of substance abuse or addiction.
- Have severe respiratory deficits.
- Have sleep apnea.
- Have liver disease.
Advice From The Pharmacist
- Avoid activities requiring mental alertness, such as driving, after taking Lorazepam.
- Don't stop taking Lorazepam suddenly unless directed by your doctor, as this can cause withdrawal symptoms.
- Avoid simultaneous use with opioids whenever possible.
- Consult your doctor if you experience mood changes or suicidal thoughts.
- Talk to your doctor or pharmacist before taking new medicines, including over-the-counter drugs and supplements, to avoid potential drug interactions.
Side Effects of Ativan
Common Side Effects
- Drowsiness
- Dizziness
- Loss of coordination
- Headache
- Nausea
- Blurred vision
- Changes in sexual interest/ability
Uncommon/Severe Side Effects
- Rash, itching/swelling (particularly of the face/tongue/throat), severe dizziness, or trouble breathing
Risks and Warnings of Ativan
- Addiction Risk: Lorazepam can cause physical and psychological dependency, especially with long-term use.
- Withdrawal Symptoms: Suddenly stopping lorazepam may cause withdrawal symptoms like sleep disturbances, hallucinations, seizures, cramping, sweating, or unusual behaviour. Scaling down use under a doctor's supervision is strongly recommended.
- Elderly Patients: Elderly patients are more prone to the sedative effects of lorazepam. Lower dosages might be needed to avoid drowsiness or dizziness.
- Pregnant or Planning to Become Pregnant: Lorazepam can potentially harm an unborn baby. Inform your healthcare professional if you are pregnant or planning to become pregnant.
- Breastfeeding Precautions: Lorazepam can pass into breast milk and may harm a nursing baby. Consult your healthcare professional before breastfeeding.
- CNS Depression: Use with other CNS depressants, including alcohol, could lead to potentially lethal respiratory depression.
Interactions with Ativan
Common Drug Interactions
- Alcohol
- Antipsychotics, like clozapine or haloperidoll
- Opioids
- Barbiturates, like phenobarbital
- Sedatives or sleep medications
Alternatives to Ativan
- Alprazolam
- Clonazepam
- Diazepam
- Phenobarbital
- Midazolam
