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Asenapine Maleate

Asenapine Maleate is the generic version of Saphris. It is an atypical antipsychotic medication prescribed primarily for the treatment of schizophrenia and bipolar disorder. Asenapine Maleate works by modulating the activity of certain neurotransmitters in the brain, particularly dopamine and serotonin, which helps manage symptoms such as hallucinations, delusions, and mood swings. This medication belongs to the drug class of atypical antipsychotics, which are known for their ability to treat psychiatric conditions with fewer side effects compared to older antipsychotic medications.


Drug Availability and Controlled Substance Status


Asenapine Maleate is available in the form of sublingual tablets, which dissolve under the tongue. It is not classified as a controlled substance, meaning it does not have a high potential for abuse or dependence. This medication is available by prescription only, and it is important for patients to use it under the supervision of a healthcare provider to ensure safe and effective treatment.



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Frequently Asked Questions

What should I do if I miss a dose of Asenapine Maleate?
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If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double the dose to make up for the missed one.

Can I drink alcohol while taking Asenapine Maleate?
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It is advisable to avoid alcohol while taking Asenapine Maleate, as alcohol can increase the sedative effects of the medication and may exacerbate side effects.

How long does it take for Asenapine Maleate to start working?
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Some patients may notice an improvement in symptoms within a few days, but it can take several weeks to experience the full effects of the medication.

Is weight gain a common side effect of Asenapine Maleate?
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Yes, weight gain is a common side effect of Asenapine Maleate, and patients should monitor their weight regularly and discuss any concerns with their healthcare provider.

Can Asenapine Maleate be used in children?
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Asenapine Maleate is FDA-approved for use in children aged 10 and older for the treatment of bipolar disorder. The safety and effectiveness of this medication in younger children have not been established.

Comprehensive Drug Guide

How Does Asenapine Maleate Work?

Asenapine Maleate works by blocking certain receptors in the brain, particularly dopamine D2 receptors and serotonin 5-HT2A receptors. By modulating the activity of these neurotransmitters, Asenapine Maleate helps reduce the symptoms of schizophrenia and bipolar disorder, such as hallucinations, delusions, and mood instability. The drug's action on these receptors also contributes to its mood-stabilizing effects, making it effective in managing both the manic and depressive phases of bipolar disorder.



Common Dosages

Common Dosages

Asenapine Maleate is commonly available in sublingual tablet forms with strengths of 5 mg and 10 mg. The tablets are designed to dissolve under the tongue and should not be swallowed or chewed. The specific dosage prescribed will depend on the patient's condition and response to treatment.


Typical Dosing


For schizophrenia, the typical starting dose of Asenapine Maleate is 5 mg twice daily. For the treatment of bipolar disorder, the typical starting dose is 10 mg twice daily, though this may be adjusted based on the patient's response and tolerance. It is important for patients to follow their healthcare provider's dosing instructions closely to ensure effective management of their condition.



Typical Dosing

FDA Approved Indications

Asenapine Maleate is FDA-approved for the treatment of schizophrenia in adults, as well as for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults and children aged 10 and older. Off-label uses may include the treatment of other psychiatric conditions as determined by a healthcare provider.



Who Shouldn't Take Asenapine Maleate?

Asenapine Maleate should not be used in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe hepatic impairment, as the drug's metabolism may be significantly affected. Patients with a history of cardiac arrhythmias should use this medication with caution due to its potential to prolong the QT interval.



Advice From The Pharmacist

Patients taking Asenapine Maleate should avoid eating or drinking for at least 10 minutes after taking the medication to ensure proper absorption. It is important to take the medication exactly as prescribed and to attend all scheduled follow-up appointments with their healthcare provider. Patients should also inform their healthcare provider of all medications and supplements they are taking to avoid potential drug interactions.



Side Effects of Asenapine Maleate

Common Side Effects

Common side effects of Asenapine Maleate include drowsiness, dizziness, and weight gain. Some patients may also experience oral hypoesthesia (numbness of the mouth) or a bitter taste. Serious side effects can include severe allergic reactions, tardive dyskinesia (involuntary movements), and neuroleptic malignant syndrome, a rare but life-threatening condition. Patients should contact their healthcare provider immediately if they experience any unusual symptoms.



Risks and Warnings of Asenapine Maleate

Asenapine Maleate carries a risk of metabolic changes, such as increased blood sugar, cholesterol, and weight gain, which can increase the risk of diabetes and cardiovascular disease. The drug may also increase the risk of death in elderly patients with dementia-related psychosis. Patients should be monitored regularly for these potential risks, and any concerns should be discussed with their healthcare provider.

Interactions with Asenapine Maleate

Common Drug Interactions

Asenapine Maleate may interact with other medications that affect the central nervous system, including other antipsychotics, antidepressants, and benzodiazepines, increasing the risk of sedation and other side effects. It may also interact with medications that prolong the QT interval, such as certain antiarrhythmics. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.



Alternatives to Asenapine Maleate

Alternative medications to Asenapine Maleate include other atypical antipsychotics such as risperidone, olanzapine, and aripiprazole. Mood stabilizers like lithium or anticonvulsants such as valproate may also be considered for the treatment of bipolar disorder. The choice of alternative treatment will depend on the patient's specific needs and response to previous medications.