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Saphris
Saphris (asenapine) is an atypical antipsychotic medication primarily used for the treatment of schizophrenia and bipolar disorder in adults and adolescents. It helps to stabilize mood and reduce the symptoms of psychosis by affecting various neurotransmitters in the brain, particularly serotonin and dopamine.
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Frequently Asked Questions
How quickly does Saphris start to work?
Patients may begin to notice improvements in their symptoms within 1 to 2 weeks, though optimal control may take longer.
Can I use Saphris while pregnant or breastfeeding?
Consult your healthcare provider before using Saphris if you are pregnant, planning to become pregnant, or breastfeeding to assess any potential risks.
Are there any specific dietary restrictions while using Saphris?
There are no specific dietary restrictions associated with the use of Saphris, but patients should avoid alcohol due to increased sedative effects.
What should I do if I miss a dose of Saphris?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Saphris safe for long-term use?
Saphris is generally considered safe for long-term use under medical supervision for managing schizophrenia and bipolar disorder. Regular follow-ups with a healthcare provider are important to monitor effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Saphris Work?
- Modulating neurotransmitter activity: Asenapine primarily blocks serotonin (5-HT2A) and dopamine (D2) receptors, which helps to reduce symptoms of schizophrenia and stabilize mood in bipolar disorder.
Common Dosages
- Sublingual tablets: Common strengths include 5 mg and 10 mg.
Typical Dosing
- For schizophrenia: The usual starting dose is 5 mg sublingually twice daily, which may be adjusted based on response and tolerability.
- For bipolar disorder: The initial dose may be 10 mg sublingually twice daily for manic episodes, with adjustments made as needed.
Typical Dosing
FDA Approved Indications
- Treatment of schizophrenia in adults and adolescents aged 13 to 17 years.
- Treatment of manic or mixed episodes associated with bipolar I disorder in adults and adolescents.
Who Shouldn't Take Saphris?
- Known hypersensitivity to asenapine or any components of the formulation.
- Severe hepatic impairment.
Advice From The Pharmacist
- Instruct patients to take Saphris sublingually (under the tongue) and to allow the tablet to dissolve completely without chewing or swallowing it.
- Advise patients to avoid eating or drinking for at least 10 minutes after taking the medication to ensure proper absorption.
- Discuss potential side effects, including sedation, dizziness, and weight gain, and encourage patients to report any severe or unusual symptoms.
Side Effects of Saphris
Common Side Effects
- Drowsiness or sedation
- Dizziness or lightheadedness
- Dry mouth
- Weight gain
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing).
- Symptoms of neuroleptic malignant syndrome (NMS), including high fever, muscle rigidity, and altered mental status.
Risks and Warnings of Saphris
- Metabolic Changes: Monitor for weight gain, dyslipidemia, and changes in glucose metabolism, particularly in patients with pre-existing risk factors.
- Suicidal Thoughts: Increased risk of suicidal thoughts and behavior has been noted in younger patients; close monitoring is advised.
Interactions with Saphris
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, particularly other central nervous system depressants, as these can increase the risk of sedation and respiratory depression.
Alternatives to Saphris
- Other Atypical Antipsychotics: Alternatives may include other antipsychotic medications such as risperidone, olanzapine, or quetiapine, depending on the specific condition and individual patient needs.
