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Arazlo
Arazlo (tazarotene) is a topical retinoid medication used primarily to treat acne vulgaris and plaque psoriasis. It is a retinoic acid derivative that helps normalize skin cell turnover and reduce inflammation, which makes it effective in treating conditions that involve clogged pores and excessive skin cell production. Arazlo is available as a lotion, making it easier to apply and less irritating compared to other forms of topical retinoids.
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Frequently Asked Questions
How long does it take for Arazlo to work?
Most patients begin to see improvements in their acne after about 4 to 8 weeks of consistent use, with full effects typically seen after 12 weeks.
Can I use Arazlo if I am pregnant?
No, Arazlo should not be used during pregnancy due to the risk of birth defects. It is classified as Pregnancy Category X.
How should I store Arazlo?
Store Arazlo at room temperature and keep it away from excessive heat or direct sunlight. Do not freeze the lotion.
Can I use Arazlo with other acne treatments?
It is best to avoid combining Arazlo with other topical acne treatments unless directed by your healthcare provider, as this can increase skin irritation.
Is Arazlo safe for long-term use?
Arazlo can be used long-term under the guidance of a healthcare provider, but regular monitoring is recommended to assess its effectiveness and tolerability over time.
Comprehensive Drug Guide
How Does Arazlo Work?
Arazlo works by binding to retinoic acid receptors (RARs) in the skin. By activating these receptors, Arazlo helps normalize the growth and differentiation of skin cells, which reduces the formation of acne lesions and controls the excessive skin cell turnover seen in psoriasis. This mechanism also helps reduce inflammation and prevent clogged pores.
Common Dosages
- Topical lotion: 0.045% tazarotene
Typical Dosing
- For acne vulgaris: Apply a thin layer of Arazlo lotion to the affected areas of the face and body once daily in the evening.
- For plaque psoriasis (off-label use): Application varies based on the severity and extent of the lesions. Always follow healthcare provider recommendations.
Typical Dosing
FDA Approved Indications
- Acne vulgaris in patients 9 years of age and older
- Plaque psoriasis (off-label use)
Who Shouldn't Take Arazlo?
- Known hypersensitivity to tazarotene or any component of the formulation
- Pregnancy, as Arazlo may cause birth defects (classified as Pregnancy Category X)
- Severe skin irritation or sunburn on the affected areas
Advice From The Pharmacist
- Apply Arazlo in the evening to clean, dry skin. Avoid contact with the eyes, mouth, and mucous membranes.
- Use sunscreen and protective clothing when outdoors, as Arazlo may increase sensitivity to sunlight.
- If your skin becomes excessively dry or irritated, you may need to reduce the frequency of application or use a moisturizer.
- Arazlo should not be used during pregnancy, as it may cause harm to the unborn baby.
Side Effects of Arazlo
Common Side Effects
- Dryness
- Redness
- Peeling
- Burning or stinging sensation
Uncommon/Severe Side Effects
- Severe skin irritation or allergic reactions
- Sensitivity to sunlight, leading to increased risk of sunburn
Risks and Warnings of Arazlo
- Photosensitivity: Arazlo increases your skin’s sensitivity to sunlight. Be sure to use sunscreen with SPF 30 or higher and avoid tanning beds while using this medication.
- Skin Irritation: Arazlo may cause skin irritation, especially during the first few weeks of treatment. If severe irritation occurs, discontinue use and contact your healthcare provider.
- Pregnancy Warning: Arazlo is classified as Pregnancy Category X and should not be used by women who are pregnant or planning to become pregnant due to the risk of birth defects.
Interactions with Arazlo
Common Drug Interactions
- Other Topical Medications: Using Arazlo with other topical acne or psoriasis treatments (such as benzoyl peroxide) may increase skin irritation.
- Photosensitizing Agents: Avoid using Arazlo with medications or products that increase sensitivity to sunlight, such as certain antibiotics (tetracyclines) or medications containing sulfur.
Alternatives to Arazlo
- Retin-A (tretinoin): Another topical retinoid used for acne, available in cream, gel, and liquid forms.
- Differin (adapalene): A topical retinoid available over-the-counter for treating mild to moderate acne.
- Tazorac (tazarotene): A cream or gel that contains a higher concentration of tazarotene (0.1%) for treating acne and psoriasis.
- Salicylic acid: An over-the-counter treatment that helps exfoliate the skin and prevent clogged pores.
