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Antara
Antara (fenofibrate) is a lipid-lowering medication used to treat high cholesterol and triglyceride levels in the blood. It belongs to the class of drugs known as fibrates, which help reduce levels of bad cholesterol (LDL) and triglycerides, while increasing good cholesterol (HDL). Antara is commonly prescribed to reduce the risk of pancreatitis in people with very high triglyceride levels, and it can also be used in combination with other lipid-lowering therapies such as statins.
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Frequently Asked Questions
How long does it take for Antara to work?
Antara typically begins lowering triglycerides and cholesterol within a few weeks, but full benefits may take up to 2-3 months of regular use.
Can I take Antara with other cholesterol-lowering medications?
Yes, but caution is needed, particularly with statins. Combining Antara with a statin can increase the risk of muscle damage (myopathy), so close monitoring by your healthcare provider is essential.
Does Antara cause weight gain?
Weight gain is not a common side effect of Antara, but maintaining a healthy diet and exercise plan is important to avoid unwanted weight changes while managing cholesterol and triglyceride levels.
What should I do if I miss a dose of Antara?
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for the missed one.
Can Antara be taken long-term?
Yes, Antara is typically prescribed for long-term use as part of a comprehensive cholesterol and triglyceride management plan. However, regular monitoring of liver function and lipid levels is necessary to ensure its continued safety and effectiveness.
Comprehensive Drug Guide
How Does Antara Work?
Antara works by activating a protein called peroxisome proliferator-activated receptor alpha (PPAR-α), which plays a key role in fat metabolism. This activation leads to increased breakdown of fatty acids and promotes the removal of triglycerides from the bloodstream. Additionally, Antara helps raise HDL (good cholesterol) and may reduce LDL (bad cholesterol) and very-low-density lipoprotein (VLDL) levels, contributing to better overall cholesterol management.
Common Dosages
- Capsules: 30 mg, 43 mg, 90 mg, and 130 mg
- The dosage is typically based on the severity of the lipid disorder and the patient's response to therapy.
Typical Dosing
- The usual recommended dose for hypertriglyceridemia or mixed dyslipidemia is 130 mg once daily.
- It is important to take Antara with food to enhance absorption and maximize its lipid-lowering effects.
Typical Dosing
FDA Approved Indications
- Hypertriglyceridemia (elevated triglycerides)
- Mixed dyslipidemia (high levels of LDL and triglycerides with low HDL)
- As an adjunct to diet and exercise to reduce cholesterol levels in patients at risk for cardiovascular disease
Who Shouldn't Take Antara?
- Severe liver disease
- Severe kidney disease or dialysis patients
- Known gallbladder disease
- Hypersensitivity to fenofibrate or any component of the formulation
Advice From The Pharmacist
- Antara should be taken once daily with food to ensure proper absorption.
- Regular blood tests may be required to monitor liver function and lipid levels during treatment.
- Notify your healthcare provider if you experience any unusual muscle pain or weakness, as fibrates can increase the risk of muscle damage (myopathy), particularly when taken with statins.
- Maintain a healthy diet and exercise routine to enhance the medication’s effectiveness.
Side Effects of Antara
Common Side Effects
- Stomach pain
- Nausea
- Headache
- Back pain
Uncommon/Severe Side Effects
- Muscle pain or weakness, which could be a sign of myopathy or rhabdomyolysis
- Liver problems, including elevated liver enzymes
- Gallstones
Risks and Warnings of Antara
- Muscle damage (myopathy/rhabdomyolysis): Antara may increase the risk of muscle damage, particularly when combined with statins. Patients should report any unexplained muscle pain, tenderness, or weakness.
- Liver function: Antara can cause liver enzyme elevations, and regular monitoring is necessary to detect liver injury early.
- Gallstones: Antara increases the risk of developing gallstones due to its effects on fat metabolism.
Interactions with Antara
Common Drug Interactions
- Statins: The combination of Antara with statins (such as simvastatin or atorvastatin) increases the risk of muscle damage (myopathy).
- Blood thinners (e.g., warfarin): Fenofibrate can increase the effects of blood thinners, raising the risk of bleeding.
- Immunosuppressants: Drugs like cyclosporine can increase the risk of kidney damage when taken with Antara.
Alternatives to Antara
- Gemfibrozil: Another fibrate used to treat high triglycerides, often preferred in patients who cannot tolerate fenofibrate.
- Statins (e.g., atorvastatin, rosuvastatin): Primarily used for lowering LDL cholesterol, but may also lower triglycerides.
- Omega-3 fatty acids: Prescription-strength fish oil (e.g., Lovaza) is used to lower triglycerides and may be used as an alternative to fibrates.
