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Amphetamine ER

Amphetamine ER, the extended-release formulation of amphetamine, is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Amphetamine belongs to the class of central nervous system stimulants, which work by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine. This helps improve focus, attention, and impulse control in individuals with ADHD, and helps manage excessive daytime sleepiness in individuals with narcolepsy.



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Frequently Asked Questions

Can I take Amphetamine ER if I have a history of heart disease?
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If you have a history of heart disease, it’s important to discuss this with your healthcare provider before starting Amphetamine ER. This medication can increase blood pressure and heart rate, which may be dangerous for individuals with pre-existing cardiovascular conditions.

What should I do if I miss a dose?
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If you miss a dose of Amphetamine ER, take it as soon as you remember, but not later in the day. If it’s close to your next dose or late in the day, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Can I drink caffeine while taking Amphetamine ER?
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While moderate caffeine intake may be acceptable, it’s advisable to limit caffeine consumption while taking Amphetamine ER, as it can increase side effects such as anxiety, jitteriness, and an increased heart rate.

How should I store this medication?
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Store Amphetamine ER at room temperature, away from moisture and heat. Keep it in a secure place, out of the reach of children and others, as it is a controlled substance with a potential for abuse.

Can I take Amphetamine ER if I am pregnant or breastfeeding?
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If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before taking Amphetamine ER. The medication may pose risks to the fetus or infant, and your provider will weigh the benefits and risks to determine the best course of action.

How long does it take for Amphetamine ER to start working?
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Amphetamine ER typically starts working within 30 to 60 minutes after taking it, with effects lasting throughout the day due to the extended-release formulation. However, it may take a few days to find the optimal dose for your needs.

Comprehensive Drug Guide

How Does Amphetamine ER Work?

Amphetamine ER works by increasing the levels of certain chemicals in the brain, such as dopamine and norepinephrine. These chemicals help improve attention, focus, and impulse control, making it easier for people with ADHD to manage their symptoms.

Common Dosages

Amphetamine ER is commonly available in extended-release capsule form with the following strengths:

  • 5 mg
  • 10 mg
  • 15 mg
  • 20 mg
  • 25 mg
  • 30 mg

These varying strengths allow for tailored dosing based on the patient's individual needs and response to the medication.


Typical Dosing


For adults and children over 6 years of age, the typical starting dose of Amphetamine ER is 10 mg taken once daily in the morning. The dosage may be adjusted by the healthcare provider in increments of 10 mg per week, with a maximum recommended dose of 30 mg per day. It’s important to take this medication in the morning to avoid interference with sleep. Amphetamine ER is not recommended for use in children under 6 years of age.



Typical Dosing

Who Shouldn't Take Amphetamine ER?

Amphetamine ER should not be used in individuals with a known hypersensitivity to amphetamines or other ingredients in the formulation. It is also contraindicated in patients with a history of cardiovascular disease, moderate to severe hypertension, hyperthyroidism, glaucoma, or a history of drug abuse. Additionally, patients who are currently taking or have recently taken monoamine oxidase inhibitors (MAOIs) should avoid Amphetamine ER due to the risk of a hypertensive crisis.



Advice From The Pharmacist

When taking Amphetamine ER, it’s important to swallow the capsule whole, without crushing or chewing it, to ensure the extended-release mechanism works properly. Take the medication in the morning with or without food. Avoid taking it in the afternoon or evening, as it can cause difficulty sleeping. Regularly monitor blood pressure and heart rate while on this medication, and avoid consuming large amounts of caffeine, as it can increase side effects. If you experience any significant mood changes, unusual behavior, or signs of an allergic reaction, contact your healthcare provider immediately.



Side Effects of Amphetamine ER

Common Side Effects

Common side effects of Amphetamine ER include decreased appetite, insomnia, dry mouth, and anxiety. More serious side effects may include increased blood pressure, rapid heart rate, mood changes, or signs of addiction or abuse. If you experience chest pain, difficulty breathing, or symptoms of severe anxiety or depression, seek medical attention right away.



Risks and Warnings of Amphetamine ER

Amphetamine ER carries a risk of abuse, dependence, and misuse, especially in individuals with a history of substance abuse. It is classified as a Schedule II controlled substance due to its potential for abuse. The medication can also increase the risk of cardiovascular events, particularly in patients with pre-existing heart conditions. Regular monitoring by a healthcare provider is essential while on this medication. Additionally, long-term use may affect growth in children, so growth should be monitored during treatment.



Interactions with Amphetamine ER

Common Drug Interactions

Amphetamine ER may interact with several other medications, including monoamine oxidase inhibitors (MAOIs), blood pressure medications, and certain antidepressants. It is also important to avoid alcohol while taking this medication, as it can increase the risk of side effects and impair judgment. Patients should inform their healthcare provider of all medications and supplements they are taking before starting Amphetamine ER.



Alternatives to Amphetamine ER

Alternative treatments to Amphetamine ER for attention deficit hyperactivity disorder (ADHD) or narcolepsy may include other stimulant medications such as methylphenidate (Ritalin, Concerta) or non-stimulant options like atomoxetine (Strattera). Behavioral therapy and lifestyle modifications may also be considered as part of a comprehensive treatment plan.