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Amjevita
Amjevita (adalimumab-atto) is a biosimilar medication to Humira (adalimumab) and is used in the treatment of various autoimmune diseases. It is a monoclonal antibody that works by inhibiting tumor necrosis factor-alpha (TNF-alpha), a substance in the body that leads to inflammation. Amjevita is indicated for the management of conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, and plaque psoriasis.
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Frequently Asked Questions
How long does it take for Amjevita to start working?
Patients may begin to notice improvements within a few weeks of starting Amjevita, but it may take several months for optimal results.
Can I take Amjevita if I have an infection?
You should not start Amjevita if you have an active infection. Consult your healthcare provider to determine if it is safe to initiate or continue treatment.
What should I do if I miss a dose of Amjevita?
If you miss a dose, administer it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Are there any specific precautions I should take while using Amjevita?
Monitor for signs of infection and report any unusual symptoms to your healthcare provider. Regular follow-up appointments for monitoring are also important.
Can I stop taking Amjevita suddenly?
Do not stop taking Amjevita without consulting your healthcare provider, as this could lead to a return of symptoms or flare-ups of the underlying condition.
Comprehensive Drug Guide
How Does Amjevita Work?
Amjevita works by specifically binding to TNF-alpha, preventing it from interacting with its receptors on the surface of cells. By inhibiting TNF-alpha, Amjevita reduces the inflammatory response that contributes to the symptoms and progression of autoimmune diseases. This action helps to decrease inflammation, pain, and damage to tissues and joints.
Common Dosages
- Injection: 40 mg/0.8 mL in a prefilled syringe
Typical Dosing
- The typical dosing for Amjevita varies based on the condition being treated. For example:
- Rheumatoid arthritis: 40 mg every other week, starting with 80 mg at week 0.
- Plaque psoriasis: 80 mg at week 0, followed by 40 mg every other week.
Typical Dosing
FDA Approved Indications
- Rheumatoid arthritis in adults
- Psoriatic arthritis in adults
- Ankylosing spondylitis
- Crohn's disease
- Ulcerative colitis
- Plaque psoriasis in adults and children aged 2 years and older
Who Shouldn't Take Amjevita?
- Known hypersensitivity to adalimumab or any components of the formulation
- Active infections, including tuberculosis (TB)
- History of serious allergic reactions to the drug
Advice From The Pharmacist
- Administer Amjevita exactly as prescribed, and follow the proper technique for subcutaneous injection.
- Monitor for signs of infections, as TNF-alpha inhibitors can increase the risk of serious infections.
- Store Amjevita in the refrigerator until use, and allow it to reach room temperature before injection.
- Inform your healthcare provider of any new symptoms or health issues, particularly signs of infections or allergic reactions.
Side Effects of Amjevita
Common Side Effects
- Injection site reactions (redness, swelling, itching)
- Headache
- Nausea
- Upper respiratory infections
Uncommon/Severe Side Effects
- Serious infections (e.g., TB, bacterial infections)
- Allergic reactions (e.g., rash, difficulty breathing)
- Malignancies (increased risk of certain types of cancer)
Risks and Warnings of Amjevita
- Infection Risk: Patients should be monitored for signs of infection before and during treatment, as TNF inhibitors can suppress the immune system.
- Malignancy Risk: There is an increased risk of certain cancers associated with TNF inhibitors; discuss this risk with your healthcare provider.
- Liver Function: Regular monitoring of liver function tests may be necessary, especially in patients with pre-existing liver conditions.
Interactions with Amjevita
Common Drug Interactions
- Other Immunosuppressants: Caution should be exercised when used with other immunosuppressive therapies, as this may further increase the risk of infections.
- Live Vaccines: Avoid live vaccines during treatment with Amjevita, as the immune response may be impaired.
Alternatives to Amjevita
- Other TNF-alpha inhibitors: Such as infliximab or certolizumab pegol for similar indications.
- Other biologics: Targeting different pathways in the immune response (e.g., IL-17 or IL-23 inhibitors) for conditions like psoriasis or inflammatory bowel disease.
- Conventional DMARDs: Such as methotrexate or sulfasalazine for rheumatoid arthritis.
